ICD-10-CM 2027
ICD-10 code for Glucocorticoid deficiency
From the official ICD-10-CM alphabetic index entry “Deficiency, deficient › glucocorticoid”. Page updated September 29, 2026.
About coding Glucocorticoid deficiency
The ICD-10-CM code for Glucocorticoid deficiency is E27.49 (Other adrenocortical insufficiency). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on E27.49.
Within E27.4, choose E27.49 (Other adrenocortical insufficiency) only when documentation doesn't support a more specific option: unspecified adrenocortical insufficiency (E27.40).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific Glucocorticoid deficiency codes (official index)
- mineralocorticoid E27.49 — Other adrenocortical insufficiency
Common questions about Glucocorticoid deficiency ICD-10 codes
What is the ICD-10 code for Glucocorticoid deficiency?
- E27.49 — Other adrenocortical insufficiency. More specific codes apply when the documentation supports them: E27.49.
What is the ICD-10 code for mineralocorticoid glucocorticoid deficiency?
- E27.49 — Other adrenocortical insufficiency.
Is E27.49 billable?
- Yes. E27.49 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E27.49 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E27.49 as a principal diagnosis.
Is E27.49 a CC or MCC?
- E27.49 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.