ICD-10-CM 2027
ICD-10 code for latent syphilis
From the official ICD-10-CM alphabetic index entry “Syphilis, syphilitic (acquired) › latent”. Page updated September 29, 2026.
About coding latent syphilis
The ICD-10-CM code for latent syphilis is A53.0 (Latent syphilis, unspecified as early or late). The official index lists 11 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on A53.0.
Within A53, choose A53.0 (Latent syphilis, unspecified as early or late) only when documentation doesn't support a more specific option: syphilis, unspecified (A53.9).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 867 (Other Infectious and Parasitic Diseases Diagnoses with MCC, relative weight 2.1859), DRG 868 (Other Infectious and Parasitic Diseases Diagnoses with CC, relative weight 1.0235) and DRG 869 (Other Infectious and Parasitic Diseases Diagnoses without CC/MCC, relative weight 0.6787), in MDC 18 (Infectious and Parasitic Diseases, Systemic or Unspecified Sites), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific latent syphilis codes (official index)
- with signs or symptoms - code by site and stage under Syphilis
- central nervous system A52.2 — Asymptomatic neurosyphilis
- date of infection unspecified A53.0 — Latent syphilis, unspecified as early or late
- early, or less than 2 years after infection A51.5 — Early syphilis, latent
- follow-up of latent syphilis A53.0 — Latent syphilis, unspecified as early or late
- date of infection unspecified A53.0 — Latent syphilis, unspecified as early or late
- late, or 2 years or more after infection A52.8 — Late syphilis, latent
- late, or 2 years or more after infection A52.8 — Late syphilis, latent
- positive serology (only finding) A53.0 — Latent syphilis, unspecified as early or late
- date of infection unspecified A53.0 — Latent syphilis, unspecified as early or late
- early, or less than 2 years after infection A51.5 — Early syphilis, latent
- late, or 2 years or more after infection A52.8 — Late syphilis, latent
Common questions about latent syphilis ICD-10 codes
What is the ICD-10 code for latent syphilis?
- A53.0 — Latent syphilis, unspecified as early or late. More specific codes apply when the documentation supports them: A52.2, A53.0, A51.5, A53.0 and others below.
What is the ICD-10 code for central nervous system latent syphilis?
- A52.2 — Asymptomatic neurosyphilis.
What is the ICD-10 code for date of infection unspecified latent syphilis?
- A53.0 — Latent syphilis, unspecified as early or late.
What is the ICD-10 code for follow-up of latent syphilis latent syphilis?
- A53.0 — Latent syphilis, unspecified as early or late.
What is the ICD-10 code for positive serology latent syphilis?
- A53.0 — Latent syphilis, unspecified as early or late.
Is A53.0 billable?
- Yes. A53.0 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can A53.0 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict A53.0 as a principal diagnosis.
Is A53.0 a CC or MCC?
- No. A53.0 is neither a CC nor an MCC under MS-DRG v44.0.