A53.0Latent syphilis, unspecified as early or late

A53.0 is the ICD-10-CM diagnosis code for latent syphilis, unspecified as early or late. It belongs to category A53 (other and unspecified syphilis), block A50-A64 (infections with a predominantly sexual mode of transmission) and chapter 1 (certain infectious and parasitic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within A53, choose A53.0 (Latent syphilis, unspecified as early or late) only when documentation doesn't support a more specific option: syphilis, unspecified (A53.9).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 867 (Other Infectious and Parasitic Diseases Diagnoses with MCC, relative weight 2.1859), DRG 868 (Other Infectious and Parasitic Diseases Diagnoses with CC, relative weight 1.0235) and DRG 869 (Other Infectious and Parasitic Diseases Diagnoses without CC/MCC, relative weight 0.6787), in MDC 18 (Infectious and Parasitic Diseases, Systemic or Unspecified Sites), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 097.1 (latent syphilis, unspecified).