ICD-10-CM 2027
ICD-10 code for Leukopenia
From the official ICD-10-CM alphabetic index entry “Leukopenia”. Page updated September 29, 2026.
About coding Leukopenia
The ICD-10-CM code for Leukopenia is D72.819 (Decreased white blood cell count, unspecified). The official index lists 12 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on D72.819.
Within D72.81, choose D72.819 (unspecified) only when documentation doesn't support a more specific option: Lymphocytopenia (D72.810) and other decreased white blood cell count (D72.818).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 814 (Reticuloendothelial and Immunity Disorders with MCC, relative weight 2.0729), DRG 815 (Reticuloendothelial and Immunity Disorders with CC, relative weight 1.0444) and DRG 816 (Reticuloendothelial and Immunity Disorders without CC/MCC, relative weight 0.7381), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific Leukopenia codes (official index)
- basophilic D72.818 — Other decreased white blood cell count
- chemotherapy (cancer) induced D70.1 — Agranulocytosis secondary to cancer chemotherapy
- congenital D70.0 — Congenital agranulocytosis
- cyclic D70.0 — Congenital agranulocytosis
- drug induced NEC D70.2 — Other drug-induced agranulocytosis
- due to cytoreductive cancer chemotherapy D70.1 — Agranulocytosis secondary to cancer chemotherapy
- eosinophilic D72.818 — Other decreased white blood cell count
- familial D70.0 — Congenital agranulocytosis
- infantile genetic D70.0 — Congenital agranulocytosis
- malignant D70.9 — Neutropenia, unspecified
- periodic D70.0 — Congenital agranulocytosis
- transitory neonatal P61.5 — Transient neonatal neutropenia
Common questions about Leukopenia ICD-10 codes
What is the ICD-10 code for Leukopenia?
- D72.819 — Decreased white blood cell count, unspecified. More specific codes apply when the documentation supports them: D72.818, D70.1, D70.0, D70.0 and others below.
What is the ICD-10 code for basophilic leukopenia?
- D72.818 — Other decreased white blood cell count.
What is the ICD-10 code for chemotherapy induced leukopenia?
- D70.1 — Agranulocytosis secondary to cancer chemotherapy.
What is the ICD-10 code for congenital leukopenia?
- D70.0 — Congenital agranulocytosis.
What is the ICD-10 code for cyclic leukopenia?
- D70.0 — Congenital agranulocytosis.
What is the ICD-10 code for drug induced nec leukopenia?
- D70.2 — Other drug-induced agranulocytosis.
What is the ICD-10 code for eosinophilic leukopenia?
- D72.818 — Other decreased white blood cell count.
Is D72.819 billable?
- Yes. D72.819 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D72.819 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D72.819 as a principal diagnosis.
Is D72.819 a CC or MCC?
- No. D72.819 is neither a CC nor an MCC under MS-DRG v44.0.