ICD-10-CM 2027
ICD-10 code for Lyell's syndrome
From the official ICD-10-CM alphabetic index entry “Lyell's syndrome”. Page updated September 29, 2026.
About coding Lyell's syndrome
The ICD-10-CM code for Lyell's syndrome is L51.2 (Toxic epidermal necrolysis [Lyell]). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on L51.2.
Within L51 (erythema multiforme), L51.2 is specifically for toxic epidermal necrolysis [Lyell]. Related codes cover Nonbullous erythema multiforme (L51.0), Stevens-Johnson syndrome (L51.1), Stevens-Johnson syndrome-toxic epidermal necrolysis overlap syndrome (L51.3), other erythema multiforme (L51.8) and unspecified (L51.9).
Use an additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5). Use an additional code to identify associated manifestations, such as: arthropathy associated with dermatological disorders (M14.8-), conjunctival edema (H11.42), conjunctivitis (H10.22-), corneal scars and opacities (H17.-), corneal ulcer (H16.0-) and 7 more.
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
More specific Lyell's syndrome codes (official index)
- due to drug L51.2 — Toxic epidermal necrolysis [Lyell]
- correct substance properly administered
- overdose or wrong substance given or taken
Common questions about Lyell's syndrome ICD-10 codes
What is the ICD-10 code for Lyell's syndrome?
- L51.2 — Toxic epidermal necrolysis [Lyell]. More specific codes apply when the documentation supports them: L51.2.
Is L51.2 billable?
- Yes. L51.2 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can L51.2 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict L51.2 as a principal diagnosis.
Is L51.2 a CC or MCC?
- L51.2 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.