ICD-10-CM 2027
ICD-10 code for Macrocytic anemia
From the official ICD-10-CM alphabetic index entry “Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › macrocytic”. Page updated September 29, 2026.
About coding Macrocytic anemia
The ICD-10-CM code for Macrocytic anemia is D53.9 (Nutritional anemia, unspecified). The official index lists 2 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on D53.9.
Within D53, choose D53.9 (Nutritional anemia, unspecified) only when documentation doesn't support a more specific option: protein deficiency anemia (D53.0), other megaloblastic anemias, not elsewhere classified (D53.1), Scorbutic anemia (D53.2) and other specified nutritional anemias (D53.8).
Don't report D53.9 together with the conditions in its Excludes1 note: anemia NOS (D64.9).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific Macrocytic anemia codes (official index)
Don't confuse with (Excludes1 for D53.9)
- anemia NOS (D64.9)
Common questions about Macrocytic anemia ICD-10 codes
What is the ICD-10 code for Macrocytic anemia?
- D53.9 — Nutritional anemia, unspecified. More specific codes apply when the documentation supports them: D52.0, D52.8.
What is the ICD-10 code for nutritional macrocytic anemia?
- D52.0 — Dietary folate deficiency anemia.
What is the ICD-10 code for tropical macrocytic anemia?
- D52.8 — Other folate deficiency anemias.
Is D53.9 billable?
- Yes. D53.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D53.9 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D53.9 as a principal diagnosis.
Is D53.9 a CC or MCC?
- No. D53.9 is neither a CC nor an MCC under MS-DRG v44.0.