D53.1Other megaloblastic anemias, not elsewhere classified

D53.1 is the ICD-10-CM diagnosis code for other megaloblastic anemias, not elsewhere classified. It belongs to category D53 (other nutritional anemias), block D50-D53 (nutritional anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D53, choose D53.1 (Other megaloblastic anemias, not elsewhere classified) only when documentation doesn't support a more specific option: protein deficiency anemia (D53.0), Scorbutic anemia (D53.2), other specified nutritional anemias (D53.8) and nutritional anemia, unspecified (D53.9).

Don't report D53.1 together with the conditions in its Excludes1 note: Di Guglielmo's disease (C94.0).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 811 (Red Blood Cell Disorders with MCC, relative weight 1.3988) and DRG 812 (Red Blood Cell Disorders without MCC, relative weight 0.9234), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 281.3 (other specified megaloblastic anemias not elsewhere classified).