ICD-10-CM 2027
ICD-10 code for megaloblastic anemia
From the official ICD-10-CM alphabetic index entry “Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › megaloblastic”. Page updated September 29, 2026.
About coding megaloblastic anemia
The ICD-10-CM code for megaloblastic anemia is D53.1 (Other megaloblastic anemias, not elsewhere classified). The official index lists 6 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on D53.1.
Within D53, choose D53.1 (Other megaloblastic anemias, not elsewhere classified) only when documentation doesn't support a more specific option: protein deficiency anemia (D53.0), Scorbutic anemia (D53.2), other specified nutritional anemias (D53.8) and nutritional anemia, unspecified (D53.9).
Don't report D53.1 together with the conditions in its Excludes1 note: Di Guglielmo's disease (C94.0).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific megaloblastic anemia codes (official index)
- combined B12 and folate deficiency D53.1 — Other megaloblastic anemias, not elsewhere classified
- hereditary D51.1 — Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with proteinuria
- nutritional D52.0 — Dietary folate deficiency anemia
- orotic aciduria D53.0 — Protein deficiency anemia
- refractory D53.1 — Other megaloblastic anemias, not elsewhere classified
- specified type NEC D53.1 — Other megaloblastic anemias, not elsewhere classified
Don't confuse with (Excludes1 for D53.1)
- Di Guglielmo's disease (C94.0)
Common questions about megaloblastic anemia ICD-10 codes
What is the ICD-10 code for megaloblastic anemia?
- D53.1 — Other megaloblastic anemias, not elsewhere classified. More specific codes apply when the documentation supports them: D53.1, D51.1, D52.0, D53.0 and others below.
What is the ICD-10 code for hereditary megaloblastic anemia?
- D51.1 — Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with proteinuria.
What is the ICD-10 code for nutritional megaloblastic anemia?
- D52.0 — Dietary folate deficiency anemia.
What is the ICD-10 code for orotic aciduria megaloblastic anemia?
- D53.0 — Protein deficiency anemia.
What is the ICD-10 code for refractory megaloblastic anemia?
- D53.1 — Other megaloblastic anemias, not elsewhere classified.
Is D53.1 billable?
- Yes. D53.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D53.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D53.1 as a principal diagnosis.
Is D53.1 a CC or MCC?
- No. D53.1 is neither a CC nor an MCC under MS-DRG v44.0.