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ICD-10-CM 2027

ICD-10 code for meningitis cryptococcosis

B45.1

Cerebral cryptococcosis

From the official ICD-10-CM alphabetic index entry “Cryptococcosis, cryptococcus (infection) (neoformans) › meningitis”. Page updated September 29, 2026.

About coding meningitis cryptococcosis

The ICD-10-CM code for meningitis cryptococcosis is B45.1 (Cerebral cryptococcosis).

Within B45 (cryptococcosis), B45.1 is specifically for cerebral cryptococcosis. Related codes cover pulmonary cryptococcosis (B45.0), cutaneous cryptococcosis (B45.2), osseous cryptococcosis (B45.3), disseminated cryptococcosis (B45.7), other forms of cryptococcosis (B45.8) and unspecified (B45.9).

As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 023 (Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator, relative weight 5.7444), DRG 024 (Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC, relative weight 3.9708), DRG 097 (Non-Bacterial Infection of Nervous System Except Viral Meningitis with MCC, relative weight 3.8226), DRG 098 (Non-Bacterial Infection of Nervous System Except Viral Meningitis with CC, relative weight 2.2706), DRG 099 (Non-Bacterial Infection of Nervous System Except Viral Meningitis without CC/MCC, relative weight 1.5256), DRG 791 (Prematurity with Major Problems, relative weight 4.1075) and 1 more, in MDC 01 (Diseases and Disorders of the Nervous System) and MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

Common questions about meningitis cryptococcosis ICD-10 codes

What is the ICD-10 code for meningitis cryptococcosis?

B45.1 — Cerebral cryptococcosis.

Is B45.1 billable?

Yes. B45.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can B45.1 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict B45.1 as a principal diagnosis.

Is B45.1 a CC or MCC?

B45.1 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.