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ICD-10-CM 2027

ICD-10 code for Misuse of drugs

F19.99

Other psychoactive substance use, unspecified with unspecified psychoactive substance-induced disorder

✓ Billable / specific

From the official ICD-10-CM alphabetic index entry “Misuse of drugs”. Page updated September 29, 2026.

About coding Misuse of drugs

The ICD-10-CM code for Misuse of drugs is F19.99 (Other psychoactive substance use, unspecified with unspecified psychoactive substance-induced disorder).

Within F19.9, choose F19.99 (with unspecified psychoactive substance-induced disorder) only when documentation doesn't support a more specific option: uncomplicated (F19.90), in remission (F19.91), with intoxication (F19.92), with withdrawal (F19.93), with psychoactive substance-induced mood disorder (F19.94), with psychoactive substance-induced psychotic disorder (F19.95), with psychoactive substance-induced persisting amnestic disorder (F19.96), with psychoactive substance-induced persisting dementia (F19.97) and 1 more.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 894 (Alcohol, Drug Abuse or Dependence, Left AMA, relative weight 0.6275), DRG 895 (Alcohol, Drug Abuse or Dependence with Rehabilitation Therapy, relative weight 1.4266), DRG 896 (Alcohol, Drug Abuse or Dependence without Rehabilitation Therapy with MCC, relative weight 1.6617) and DRG 897 (Alcohol, Drug Abuse or Dependence without Rehabilitation Therapy without MCC, relative weight 0.8584), in MDC 20 (Alcohol/Drug Use and Alcohol/Drug Induced Organic Mental Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

Common questions about Misuse of drugs ICD-10 codes

What is the ICD-10 code for Misuse of drugs?

F19.99 — Other psychoactive substance use, unspecified with unspecified psychoactive substance-induced disorder.

Is F19.99 billable?

Yes. F19.99 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can F19.99 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict F19.99 as a principal diagnosis.

Is F19.99 a CC or MCC?

No. F19.99 is neither a CC nor an MCC under MS-DRG v44.0.