ICD-10-CM 2027
ICD-10 code for neurosyphilis
From the official ICD-10-CM alphabetic index entry “Neurosyphilis (arrested) (early) (gumma) (late) (latent) (recurrent) (relapse)”. Page updated September 29, 2026.
About coding neurosyphilis
The ICD-10-CM code for neurosyphilis is A52.3 (Neurosyphilis, unspecified). The official index lists 27 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on A52.3.
Within A52, choose A52.3 (Neurosyphilis, unspecified) only when documentation doesn't support a more specific option: cardiovascular and cerebrovascular syphilis (A52.0), symptomatic neurosyphilis (A52.1), Asymptomatic neurosyphilis (A52.2), other symptomatic late syphilis (A52.7), latent (A52.8) and unspecified (A52.9).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 056 (Degenerative Nervous System Disorders with MCC, relative weight 2.2655) and DRG 057 (Degenerative Nervous System Disorders without MCC, relative weight 1.2838), in MDC 01 (Diseases and Disorders of the Nervous System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific neurosyphilis codes (official index)
- with ataxia (cerebellar) (locomotor) (spastic) (spinal) A52.19 — Other symptomatic neurosyphilis
- aneurysm (cerebral) A52.05 — Other cerebrovascular syphilis
- arachnoid (adhesive) A52.13 — Late syphilitic meningitis
- arteritis (any artery) (cerebral) A52.04 — Syphilitic cerebral arteritis
- asymptomatic A52.2 — Asymptomatic neurosyphilis
- congenital A50.40 — Late congenital neurosyphilis, unspecified
- dura (mater) A52.13 — Late syphilitic meningitis
- general paresis A52.17 — General paresis
- hemorrhagic A52.05 — Other cerebrovascular syphilis
- juvenile (asymptomatic) (meningeal) A50.40 — Late congenital neurosyphilis, unspecified
- leptomeninges (aseptic) A52.13 — Late syphilitic meningitis
- meningeal, meninges (adhesive) A52.13 — Late syphilitic meningitis
- meningitis A52.13 — Late syphilitic meningitis
- meningovascular (diffuse) A52.13 — Late syphilitic meningitis
- optic atrophy A52.15 — Late syphilitic neuropathy
- parenchymatous (degenerative) A52.19 — Other symptomatic neurosyphilis
- paresis, paretic A52.17 — General paresis
- juvenile A50.45 — Juvenile general paresis
- remission in (sustained) A52.3 — Neurosyphilis, unspecified
- serological (without symptoms) A52.2 — Asymptomatic neurosyphilis
- specified nature or site NEC A52.19 — Other symptomatic neurosyphilis
- tabes, tabetic (dorsalis) A52.11 — Tabes dorsalis
- juvenile A50.45 — Juvenile general paresis
- taboparesis (taboparetic) A52.17 — General paresis
- juvenile A50.45 — Juvenile general paresis
- thrombosis (cerebral) A52.05 — Other cerebrovascular syphilis
- vascular (cerebral) NEC A52.05 — Other cerebrovascular syphilis
Common questions about neurosyphilis ICD-10 codes
What is the ICD-10 code for neurosyphilis?
- A52.3 — Neurosyphilis, unspecified. More specific codes apply when the documentation supports them: A52.19, A52.05, A52.13, A52.04 and others below.
What is the ICD-10 code for aneurysm neurosyphilis?
- A52.05 — Other cerebrovascular syphilis.
What is the ICD-10 code for arachnoid neurosyphilis?
- A52.13 — Late syphilitic meningitis.
What is the ICD-10 code for arteritis neurosyphilis?
- A52.04 — Syphilitic cerebral arteritis.
What is the ICD-10 code for asymptomatic neurosyphilis?
- A52.2 — Asymptomatic neurosyphilis.
What is the ICD-10 code for congenital neurosyphilis?
- A50.40 — Late congenital neurosyphilis, unspecified.
What is the ICD-10 code for dura neurosyphilis?
- A52.13 — Late syphilitic meningitis.
Is A52.3 billable?
- Yes. A52.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can A52.3 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict A52.3 as a principal diagnosis.
Is A52.3 a CC or MCC?
- A52.3 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.