ICD-10-CM 2027
ICD-10 code for porphyria
From the official ICD-10-CM alphabetic index entry “Porphyria (South African)”. Page updated September 29, 2026.
About coding porphyria
The ICD-10-CM code for porphyria is E80.20 (Unspecified porphyria). The official index lists 9 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E80.20.
Within E80.2, choose E80.20 (Unspecified porphyria) only when documentation doesn't support a more specific option: acute intermittent (hepatic) porphyria (E80.21) and other porphyria (E80.29).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific porphyria codes (official index)
- acquired E80.20 — Unspecified porphyria
- acute intermittent (hepatic) (Swedish) E80.21 — Acute intermittent (hepatic) porphyria
- cutanea tarda (hereditary) (symptomatic) E80.1 — Porphyria cutanea tarda
- due to drugs E80.20 — Unspecified porphyria
- correct substance properly administered
- overdose or wrong substance given or taken
- erythropoietic (congenital) (hereditary) E80.0 — Hereditary erythropoietic porphyria
- hepatocutaneous type E80.1 — Porphyria cutanea tarda
- secondary E80.20 — Unspecified porphyria
- toxic NEC E80.20 — Unspecified porphyria
- variegata E80.20 — Unspecified porphyria
Common questions about porphyria ICD-10 codes
What is the ICD-10 code for porphyria?
- E80.20 — Unspecified porphyria. More specific codes apply when the documentation supports them: E80.20, E80.21, E80.1, E80.20 and others below.
What is the ICD-10 code for acquired porphyria?
- E80.20 — Unspecified porphyria.
What is the ICD-10 code for acute intermittent porphyria?
- E80.21 — Acute intermittent (hepatic) porphyria.
What is the ICD-10 code for cutanea tarda porphyria?
- E80.1 — Porphyria cutanea tarda.
What is the ICD-10 code for erythropoietic porphyria?
- E80.0 — Hereditary erythropoietic porphyria.
What is the ICD-10 code for hepatocutaneous type porphyria?
- E80.1 — Porphyria cutanea tarda.
What is the ICD-10 code for secondary porphyria?
- E80.20 — Unspecified porphyria.
Is E80.20 billable?
- Yes. E80.20 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E80.20 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E80.20 as a principal diagnosis.
Is E80.20 a CC or MCC?
- E80.20 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.