ICD-10-CM 2027
ICD-10 code for Prothrombin gene mutation
From the official ICD-10-CM alphabetic index entry “Mutation (s) › prothrombin gene”. Page updated September 29, 2026.
About coding Prothrombin gene mutation
The ICD-10-CM code for Prothrombin gene mutation is D68.52 (Prothrombin gene mutation).
Within D68.5 (primary thrombophilia), D68.52 is specifically for Prothrombin gene mutation. Related codes cover activated protein C resistance (D68.51) and other primary thrombophilia (D68.59).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 814 (Reticuloendothelial and Immunity Disorders with MCC, relative weight 2.0729), DRG 815 (Reticuloendothelial and Immunity Disorders with CC, relative weight 1.0444) and DRG 816 (Reticuloendothelial and Immunity Disorders without CC/MCC, relative weight 0.7381), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about Prothrombin gene mutation ICD-10 codes
What is the ICD-10 code for Prothrombin gene mutation?
- D68.52 — Prothrombin gene mutation.
Is D68.52 billable?
- Yes. D68.52 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D68.52 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D68.52 as a principal diagnosis.
Is D68.52 a CC or MCC?
- D68.52 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.