ICD-10-CM 2027
ICD-10 code for second generation des
From the official ICD-10-CM alphabetic index entry “DES › second generation”. Page updated September 29, 2026.
About coding second generation des
The ICD-10-CM code for second generation des is Z91.B (Personal risk factor of exposure to diethylstilbestrol).
Within Z91 (personal risk factors, not elsewhere classified), Z91.B is specifically for personal risk factor of exposure to diethylstilbestrol. Related codes cover allergy status, other than to drugs and biological substances (Z91.0), patient's noncompliance with medical treatment and regimen (Z91.1), personal history of psychological trauma, not elsewhere classified (Z91.4), personal history of self-harm (Z91.5), other specified personal risk factors, not elsewhere classified (Z91.8) and Caregiver's noncompliance with patient's medical treatment and regimen (Z91.A).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 951 (Other Factors Influencing Health Status, relative weight 0.5577), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about second generation des ICD-10 codes
What is the ICD-10 code for second generation des?
- Z91.B — Personal risk factor of exposure to diethylstilbestrol.
Is Z91.B billable?
- Yes. Z91.B is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can Z91.B be used as a principal diagnosis?
- No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.
Is Z91.B a CC or MCC?
- No. Z91.B is neither a CC nor an MCC under MS-DRG v44.0.