ICD-10-CM 2027
ICD-10 code for serum allergy
From the official ICD-10-CM alphabetic index entry “Allergy, allergic (reaction) (to) › serum”. Page updated September 29, 2026.
About coding serum allergy
The ICD-10-CM code for serum allergy is T80.69 (Other serum reaction due to other serum). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on T80.69.
Within T80.6, choose T80.69 (other serum) only when documentation doesn't support a more specific option: administration of blood and blood products (T80.61) and vaccination (T80.62).
Codes in this range require a 7th character: A for initial encounter, D for subsequent encounter and S for sequela. Use placeholder "X" characters to fill any empty positions before the 7th character.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
More specific serum allergy codes (official index)
- anaphylactic shock T80.59 — Anaphylactic reaction due to other serum
Common questions about serum allergy ICD-10 codes
What is the ICD-10 code for serum allergy?
- T80.69 — Other serum reaction due to other serum (a header code; report a more specific subcode). More specific codes apply when the documentation supports them: T80.59.
What is the ICD-10 code for anaphylactic shock serum allergy?
- T80.59 — Anaphylactic reaction due to other serum (header code; choose a more specific subcode).
Is T80.69 billable?
- No. T80.69 is a header code. Report one of its more specific subcodes instead.