ICD-10-CM 2027
ICD-10 code for serum reaction
From the official ICD-10-CM alphabetic index entry “Reaction › serum”. Page updated September 29, 2026.
About coding serum reaction
The ICD-10-CM code for serum reaction is T80.69 (Other serum reaction due to other serum). The official index lists 5 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on T80.69.
Within T80.6, choose T80.69 (other serum) only when documentation doesn't support a more specific option: administration of blood and blood products (T80.61) and vaccination (T80.62).
Codes in this range require a 7th character: A for initial encounter, D for subsequent encounter and S for sequela. Use placeholder "X" characters to fill any empty positions before the 7th character.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
More specific serum reaction codes (official index)
- anaphylactic (immediate) T80.59 — Anaphylactic reaction due to other serum
- specified reaction NEC
- due to
- administration of blood and blood products T80.61 — Other serum reaction due to administration of blood and blood products
- immunization T80.62 — Other serum reaction due to vaccination
- serum specified NEC T80.69 — Other serum reaction due to other serum
- vaccination T80.62 — Other serum reaction due to vaccination
Common questions about serum reaction ICD-10 codes
What is the ICD-10 code for serum reaction?
- T80.69 — Other serum reaction due to other serum (a header code; report a more specific subcode). More specific codes apply when the documentation supports them: T80.59, T80.61, T80.62, T80.69 and others below.
What is the ICD-10 code for anaphylactic serum reaction?
- T80.59 — Anaphylactic reaction due to other serum (header code; choose a more specific subcode).
Is T80.69 billable?
- No. T80.69 is a header code. Report one of its more specific subcodes instead.