ICD-10-CM 2027
ICD-10 code for Succinic semialdehyde dehydrogenase deficiency
Disorders of gamma aminobutyric acid metabolism
From the official ICD-10-CM alphabetic index entry “Deficiency, deficient › succinic semialdehyde dehydrogenase”. Page updated September 29, 2026.
About coding Succinic semialdehyde dehydrogenase deficiency
The ICD-10-CM code for Succinic semialdehyde dehydrogenase deficiency is E72.81 (Disorders of gamma aminobutyric acid metabolism).
Within E72.8 (other specified disorders of amino-acid metabolism), E72.81 is specifically for disorders of gamma aminobutyric acid metabolism. Related codes cover other specified disorders of amino-acid metabolism (E72.89).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about Succinic semialdehyde dehydrogenase deficiency ICD-10 codes
What is the ICD-10 code for Succinic semialdehyde dehydrogenase deficiency?
- E72.81 — Disorders of gamma aminobutyric acid metabolism.
Is E72.81 billable?
- Yes. E72.81 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E72.81 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E72.81 as a principal diagnosis.
Is E72.81 a CC or MCC?
- E72.81 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.