ICD-10-CM 2027
ICD-10 code for thyroid nodule
From the official ICD-10-CM alphabetic index entry “Nodule (s), nodular › thyroid (cold) (gland) (nontoxic)”. Page updated September 29, 2026.
About coding thyroid nodule
The ICD-10-CM code for thyroid nodule is E04.1 (Nontoxic single thyroid nodule). The official index lists 4 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on E04.1.
Within E04 (other nontoxic goiter), E04.1 is specifically for nontoxic single thyroid nodule. Related codes cover nontoxic diffuse goiter (E04.0), nontoxic multinodular goiter (E04.2), other specified nontoxic goiter (E04.8) and nontoxic goiter, unspecified (E04.9).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 011 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC, relative weight 5.6154), DRG 012 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC, relative weight 4.381), DRG 013 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC, relative weight 2.7307), DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in Pre-MDC and MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific thyroid nodule codes (official index)
- with thyrotoxicosis E05.20 — Thyrotoxicosis with toxic multinodular goiter without thyrotoxic crisis or storm
- with thyroid storm E05.21 — Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm
- toxic or with hyperthyroidism E05.20 — Thyrotoxicosis with toxic multinodular goiter without thyrotoxic crisis or storm
- with thyroid storm E05.21 — Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm
Common questions about thyroid nodule ICD-10 codes
What is the ICD-10 code for thyroid nodule?
- E04.1 — Nontoxic single thyroid nodule. More specific codes apply when the documentation supports them: E05.20, E05.21, E05.20, E05.21.
What is the ICD-10 code for toxic or with hyperthyroidism thyroid nodule?
- E05.20 — Thyrotoxicosis with toxic multinodular goiter without thyrotoxic crisis or storm.
Is E04.1 billable?
- Yes. E04.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E04.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E04.1 as a principal diagnosis.
Is E04.1 a CC or MCC?
- No. E04.1 is neither a CC nor an MCC under MS-DRG v44.0.