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ICD-10-CM 2027 diagnosis code

E04.1Nontoxic single thyroid nodule

✓ Billable / specific

E04.1 is a valid, billable ICD-10-CM code for nontoxic single thyroid nodule. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Looking up by condition? See ICD-10 code for Colloid nodule, ICD-10 code for Thyroid nodule, ICD-10 code for Uninodular nontoxic goiter.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E04.1

E04.1 is the ICD-10-CM diagnosis code for nontoxic single thyroid nodule. It belongs to category E04 (other nontoxic goiter), block E00-E07 (disorders of thyroid gland) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E04 (other nontoxic goiter), E04.1 is specifically for nontoxic single thyroid nodule. Related codes cover nontoxic diffuse goiter (E04.0), nontoxic multinodular goiter (E04.2), other specified nontoxic goiter (E04.8) and nontoxic goiter, unspecified (E04.9).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 011 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC, relative weight 5.6154), DRG 012 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC, relative weight 4.381), DRG 013 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC, relative weight 2.7307), DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in Pre-MDC and MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 241.0 (nontoxic uninodular goiter) and 246.2 (cyst of thyroid).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Colloid nodule (cystic) (thyroid)
  • Nontoxic uninodular goiter
  • Thyroid (cystic) nodule NOS

Notes that apply from higher levels

Instructions written at a parent level also apply to E04.1.

› From E04 Other nontoxic goiter
Excludes1
  • congenital goiter (NOS) (diffuse) (parenchymatous) (E03.0)
  • iodine-deficiency related goiter (E00-E02)

Broader instructions also apply from Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

8 entries

Terms in the official ICD-10-CM index that lead to E04.1.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 241.0Nontoxic uninodular goiterapproximate
  • 246.2Cyst of thyroidapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E04.1

Is E04.1 billable?

Yes. E04.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E04.1 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E04.1 as a principal diagnosis.

Is E04.1 a CC or MCC?

No. E04.1 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does E04.1 group to?

E04.1 is used in the MS-DRG v44.0 logic for MS-DRG 011 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC), MS-DRG 012 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC), MS-DRG 013 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC), MS-DRG 643 (Endocrine Disorders with MCC), MS-DRG 644 (Endocrine Disorders with CC) and MS-DRG 645 (Endocrine Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for E04.1?

The CMS General Equivalence Mappings map E04.1 to ICD-9-CM 241.0 and 246.2.