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ICD-10-PCS 2027 procedure code

3E00XGFIntroduction of Other Enzymatic/Chemical Agent into Skin and Mucous Membranes, External Approach

✓ Valid for 2027New for 2027

Short description: Introduce Oth Enzym/Chem Agt in Skin/Mucous Mem, Extern

Code last changed in FY2027 (effective October 1, 2026). Source: official FY2027 ICD-10-PCS release from CMS. Page updated September 29, 2026. About our data

About 3E00XGF

3E00XGF is the ICD-10-PCS code for a introduction procedure on the skin and mucous membranes using an external approach with other therapeutic substance (qualifier: other enzymatic/chemical agent). In ICD-10-PCS, introduction means putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

For a different body part, codes include 3E01XGF (subcutaneous tissue).

It doesn't appear in the MS-DRG procedure index, so on its own it doesn't change the DRG assignment.

It was added in FY2027, effective October 1, 2026.

What each character means

1. Section
3Administration
2. Body System
EPhysiological Systems and Anatomical Regions
3. Operation
0Introduction

Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products

4. Body System / Region
0Skin and Mucous Membranes
5. Approach
XExternal

Procedures performed directly on the skin or mucous membrane and procedures performed indirectly by the application of external force through the skin or mucous membrane

6. Substance
GOther Therapeutic Substance

Includes: Anacaulase-bcdb; Bromelain-enriched Proteolytic Enzyme; Collagenase SANTYL Ointment; COSELA(tm) (Trilaciclib); ENSPRYNG(tm) (Satralizumab-mwge); Fostamatinib; Idarucizumab, Pradaxa(R)(dabigatran) reversal agent; NexoBrid(tm); Praxbind(R) (idarucizumab), Pradaxa(R)(dabigatran) reversal agent; SANTYL Ointment; Satralizumab-mwge; TAVALISSE(R); Trilaciclib

7. Qualifier
FOther Enzymatic/Chemical Agent

Other versions of this procedure

Different body system / region

Different qualifier

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2027 (effective 10/1/2026): Added

Common questions about 3E00XGF

Is 3E00XGF a valid ICD-10-PCS code for 2027?

Yes. 3E00XGF is valid for inpatient procedures from October 1, 2026 through September 30, 2027.