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ICD-10-PCS 2027 procedure code

3E0330MIntroduction of Antineoplastic, Monoclonal Antibody, into Peripheral Vein, Percutaneous Approach

✓ Valid for 2027

Short description: Introduce Antneo, Moncln Ab, in Periph Vein, Perc

Code last changed in FY2022 (effective October 1, 2021). Source: official FY2027 ICD-10-PCS release from CMS. Page updated September 29, 2026. About our data

About 3E0330M

3E0330M is the ICD-10-PCS code for a introduction procedure on the peripheral vein using a percutaneous approach with antineoplastic (qualifier: monoclonal antibody). In ICD-10-PCS, introduction means putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

In plain terms, this corresponds to injection or infusion of biological response modifier [BRM] as an antineoplastic agent, the ICD-9-CM procedure title it maps to (99.28).

For a different body part, codes include 3E0130M (subcutaneous tissue), 3E0230M (muscle), 3E0430M (central vein), 3E0530M (peripheral artery), 3E0630M (central artery), 3E0930M (nose) and 21 more.

The same procedure with a different approach is coded 3E0300M (open).

It doesn't appear in the MS-DRG procedure index, so on its own it doesn't change the DRG assignment.

It has been valid since ICD-10-PCS took effect on October 1, 2015.

What each character means

1. Section
3Administration
2. Body System
EPhysiological Systems and Anatomical Regions
3. Operation
0Introduction

Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products

4. Body System / Region
3Peripheral Vein
5. Approach
3Percutaneous

Entry, by puncture or minor incision, of instrumentation through the skin or mucous membrane and any other body layers necessary to reach the site of the procedure

6. Substance
0Antineoplastic

Includes: Amivantamab Monoclonal Antibody; Lurbinectedin; RYBREVANT (tm) (Amivantamab Monoclonal Antibody); ZEPZELCA(tm) (Lurbinectedin)

7. Qualifier
MMonoclonal Antibody

Other versions of this procedure

Different approach

ICD-9-CM equivalent

Converter →
  • 99.28Injection or infusion of biological response modifier [BRM] as an antineoplastic agentapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • FY2022 (effective 10/1/2021): Title revised — was “Introduction of Monoclonal Antibody into Peripheral Vein, Percutaneous Approach”

Common questions about 3E0330M

Is 3E0330M a valid ICD-10-PCS code for 2027?

Yes. 3E0330M is valid for inpatient procedures from October 1, 2026 through September 30, 2027.

What is the ICD-9 procedure code for 3E0330M?

The CMS GEMs map 3E0330M to ICD-9-CM 99.28 (Injection or infusion of biological response modifier [BRM] as an antineoplastic agent).