ICD-9-CM procedure code (retired)
99.28 — Injection or infusion of biological response modifier [BRM] as an antineoplastic agent
About ICD-9-CM 99.28
99.28 is an ICD-9-CM procedure code for injection or infusion of biological response modifier [BRM] as an antineoplastic agent. ICD-9-CM was retired for U.S. claims on October 1, 2015, when ICD-10-PCS took over.
The CMS General Equivalence Mappings translate it to 11 ICD-10-PCS codes, such as 3E00X0M (Introduction of Antineoplastic, Monoclonal Antibody, into Skin and Mucous Membranes, External Approach), 3E0130M (Introduction of Antineoplastic, Monoclonal Antibody, into Subcutaneous Tissue, Percutaneous Approach) and 3E0230M (Introduction of Antineoplastic, Monoclonal Antibody, into Muscle, Percutaneous Approach). All of these are approximate matches, so review the record to pick the right one.
ICD-10-PCS equivalents
- 3E00X0MIntroduction of Antineoplastic, Monoclonal Antibody, into Skin and Mucous Membranes, External Approachapproximate
- 3E0130MIntroduction of Antineoplastic, Monoclonal Antibody, into Subcutaneous Tissue, Percutaneous Approachapproximate
- 3E0230MIntroduction of Antineoplastic, Monoclonal Antibody, into Muscle, Percutaneous Approachapproximate
- 3E03303Introduction of Low-dose Interleukin-2 into Peripheral Vein, Percutaneous Approachapproximate
- 3E0330MIntroduction of Antineoplastic, Monoclonal Antibody, into Peripheral Vein, Percutaneous Approachapproximate
- 3E04303Introduction of Low-dose Interleukin-2 into Central Vein, Percutaneous Approachapproximate
- 3E0430MIntroduction of Antineoplastic, Monoclonal Antibody, into Central Vein, Percutaneous Approachapproximate
- 3E05303Introduction of Low-dose Interleukin-2 into Peripheral Artery, Percutaneous Approachapproximate
- 3E0530MIntroduction of Antineoplastic, Monoclonal Antibody, into Peripheral Artery, Percutaneous Approachapproximate
- 3E06303Introduction of Low-dose Interleukin-2 into Central Artery, Percutaneous Approachapproximate
- 3E0630MIntroduction of Antineoplastic, Monoclonal Antibody, into Central Artery, Percutaneous Approachapproximate
Common questions about 99.28
What is the ICD-10 code for ICD-9 99.28?
- The GEMs map 99.28 to ICD-10-PCS 3E00X0M, 3E0130M, 3E0230M, 3E03303, 3E0330M, 3E04303 and 5 more.
GEMs are a translation aid, not a substitute for coding from the record. The 2027 ICD-10 code set has changed since the last GEMs release in 2018. Page updated September 29, 2026.