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ICD-10-PCS 2027 procedure code

3E0Q005Introduction of Other Antineoplastic into Cranial Cavity and Brain, Open Approach

✓ Valid for 2027Non-O.R. procedure

Short description: Introduce Oth Antineoplastic in Cran Cav/Brain, Open

Code last changed in FY2017 (effective October 1, 2016). Source: official FY2027 ICD-10-PCS release from CMS. Page updated September 29, 2026. About our data

About 3E0Q005

3E0Q005 is the ICD-10-PCS code for a introduction procedure on the cranial cavity and brain using an open approach with antineoplastic (qualifier: other antineoplastic). In ICD-10-PCS, introduction means putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

In plain terms, this corresponds to implantation of chemotherapeutic agent, the ICD-9-CM procedure title it maps to (00.10).

For a different body part, codes include 3E03005 (peripheral vein), 3E04005 (central vein), 3E05005 (peripheral artery) and 3E06005 (central artery).

The same procedure with a different approach is coded 3E0Q305 (percutaneous) and 3E0Q705 (via natural or artificial opening).

It is a non-O.R. procedure that is part of the MS-DRG logic for DRG 023 (Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis with MCC or Antineoplastic Implant or Epilepsy with Neurostimulator) and DRG 024 (Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis without MCC), under the surgical category “Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis”.

It was added in FY2017, effective October 1, 2016.

What each character means

1. Section
3Administration
2. Body System
EPhysiological Systems and Anatomical Regions
3. Operation
0Introduction

Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products

4. Body System / Region
QCranial Cavity and Brain
5. Approach
0Open

Cutting through the skin or mucous membrane and any other body layers necessary to expose the site of the procedure

6. Substance
0Antineoplastic

Includes: Amivantamab Monoclonal Antibody; Lurbinectedin; RYBREVANT (tm) (Amivantamab Monoclonal Antibody); ZEPZELCA(tm) (Lurbinectedin)

7. Qualifier
5Other Antineoplastic

Other versions of this procedure

MS-DRG v44.0 grouping

All DRGs →

Surgical MS-DRGs this procedure can group to, depending on the principal diagnosis's MDC.

ICD-9-CM equivalent

Converter →
  • 00.10Implantation of chemotherapeutic agentapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2017 (effective 10/1/2016): Added
  • No changes since FY2017.

Common questions about 3E0Q005

Is 3E0Q005 a valid ICD-10-PCS code for 2027?

Yes. 3E0Q005 is valid for inpatient procedures from October 1, 2026 through September 30, 2027.

Is 3E0Q005 an O.R. procedure?

No. 3E0Q005 is designated non-O.R. in MS-DRG v44.0.

What DRG does 3E0Q005 group to?

Depending on the principal diagnosis, 3E0Q005 can group to MS-DRG 023 and MS-DRG 024.

What is the ICD-9 procedure code for 3E0Q005?

The CMS GEMs map 3E0Q005 to ICD-9-CM 00.10 (Implantation of chemotherapeutic agent).