C46.1Kaposi's sarcoma of soft tissue

C46.1 is the ICD-10-CM diagnosis code for Kaposi's sarcoma of soft tissue. It belongs to category C46 (Kaposi's sarcoma), block C45-C49 (malignant neoplasms of mesothelial and soft tissue) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within C46 (Kaposi's sarcoma), C46.1 is specifically for Kaposi's sarcoma of soft tissue. Related codes cover of skin (C46.0), of palate (C46.2), of lymph nodes (C46.3), of gastrointestinal sites (C46.4), of lung (C46.5), of other sites (C46.7) and unspecified (C46.9).

The conditions in its Excludes2 note aren't part of C46.1, but may be coded alongside it if the patient has both: Kaposi's sarcoma of lymph glands and nodes (C46.3).

Code first: any human immunodeficiency virus [HIV] disease (B20).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 606 (Minor Skin Disorders with MCC, relative weight 1.5728), DRG 607 (Minor Skin Disorders without MCC, relative weight 0.8772), DRG 974 (HIV with Major Related Condition with MCC, relative weight 3.0506), DRG 975 (HIV with Major Related Condition with CC, relative weight 1.3252) and DRG 976 (HIV with Major Related Condition without CC/MCC, relative weight 0.8124), in MDC 09 (Diseases and Disorders of the Skin, Subcutaneous Tissue and Breast) and MDC 25 (Human Immunodeficiency Virus Infections), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 176.1 (Kaposi's sarcoma, soft tissue).