C49Malignant neoplasm of other connective and soft tissue

C49 is the ICD-10-CM diagnosis code for malignant neoplasm of other connective and soft tissue. It belongs to block C45-C49 (malignant neoplasms of mesothelial and soft tissue) and chapter 2 (neoplasms). It is a header code, so it can't be reported by itself; one of its 10 subcodes must be used instead.

To report this condition, pick the subcode that matches the documentation: C49.0 (neck), C49.1 (shoulder), C49.2 (hip), C49.3 (thorax), C49.4 (abdomen), C49.5 (pelvis), C49.6 (unspecified), C49.8 (tissue) and 2 more.

Don't report C49 together with the conditions in its Excludes1 note: articular (C40-C41), larynx (C32.3), nose (C30.0) and malignant neoplasm of connective tissue of breast (C50.-).

The conditions in its Excludes2 note aren't part of C49, but may be coded alongside it if the patient has both: Kaposi's sarcoma of soft tissue (C46.1), malignant neoplasm of heart (C38.0), malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-), malignant neoplasm of peritoneum (C48.2) and 3 more.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.