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ICD-10-CM 2027 diagnosis code

C96.2Malignant mast cell neoplasm

Not billable — use a more specific code

C96.2 is a header code, so it can't be reported by itself. Choose one of the 4 more specific codes beneath it.

Code last changed in FY2018 (effective October 1, 2017). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About C96.2

C96.2 is the ICD-10-CM diagnosis code for malignant mast cell neoplasm. It belongs to category C96 (other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue), block C81-C96 (malignant neoplasms of lymphoid, hematopoietic and related tissue) and chapter 2 (neoplasms). It is a header code, so it can't be reported by itself; one of its 4 subcodes must be used instead.

Within C96 (other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue), C96.2 is specifically for malignant mast cell neoplasm. Related codes cover multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis (C96.0), sarcoma of dendritic cells (accessory cells) (C96.4), multifocal and unisystemic Langerhans-cell histiocytosis (C96.5), Unifocal Langerhans-cell histiocytosis (C96.6), malignant neoplasm of lymphoid, hematopoietic and related tissue, unspecified (C96.9), histiocytic sarcoma (C96.A) and other specified malignant neoplasms of lymphoid, hematopoietic and related tissue (C96.Z).

To report this condition, pick the subcode that matches the documentation: C96.20 (unspecified), C96.21 (mastocytosis), C96.22 (sarcoma) and C96.29 (neoplasm).

Don't report C96.2 together with the conditions in its Excludes1 note: indolent mastocytosis (D47.02), mast cell leukemia (C94.30) and mastocytosis (congenital) (cutaneous) (Q82.2).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2018 (title revised).

Specific codes under C96.2

Coding notes

Excludes1Not coded here — never report together with this code
  • indolent mastocytosis (D47.02)
  • mast cell leukemia (C94.30)
  • mastocytosis (congenital) (cutaneous) (Q82.2)

Notes that apply from higher levels

Instructions written at a parent level also apply to C96.2.

› From C96 Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue
Excludes1
  • personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79)

Broader instructions also apply from C81-C96 Malignant neoplasms of lymphoid, hematopoietic and related tissue and Chapter 2: Neoplasms.

Codes whose notes reference C96.2

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • FY2018 (effective 10/1/2017): Title revised — was “Malignant mast cell tumor”

Common questions about C96.2

Is C96.2 billable?

No. C96.2 is a header code. Report one of its more specific subcodes instead.