ICD-10-CM 2027 diagnosis code
D51.0Vitamin B12 deficiency anemia due to intrinsic factor deficiency
D51.0 is a valid, billable ICD-10-CM code for vitamin b12 deficiency anemia due to intrinsic factor deficiency. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Vitamin B12 defic anemia due to intrinsic factor deficiency
Looking up by condition? See ICD-10 code for Addison-Biermer anemia, ICD-10 code for Biermer's anemia or disease, ICD-10 code for Lichtheim's disease or syndrome.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About D51.0
D51.0 is the ICD-10-CM diagnosis code for vitamin B12 deficiency anemia due to intrinsic factor deficiency. It belongs to category D51 (vitamin B12 deficiency anemia), block D50-D53 (nutritional anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within D51 (vitamin B12 deficiency anemia), D51.0 is specifically for vitamin B12 deficiency anemia due to intrinsic factor deficiency. Related codes cover due to selective vitamin B12 malabsorption with proteinuria (D51.1), Transcobalamin II deficiency (D51.2), other dietary vitamin B12 deficiency anemia (D51.3), other vitamin B12 deficiency anemias (D51.8) and unspecified (D51.9).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 811 (Red Blood Cell Disorders with MCC, relative weight 1.3988) and DRG 812 (Red Blood Cell Disorders without MCC, relative weight 0.9234), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 281.0 (pernicious anemia).
Coding notes
- Addison anemia
- Biermer anemia
- Pernicious (congenital) anemia
- Congenital intrinsic factor deficiency
Notes that apply from higher levels
Instructions written at a parent level also apply to D51.0.
› From D51 Vitamin B12 deficiency anemia
- deficiency of other B group vitamins (E53-)
Broader instructions also apply from Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.
Alphabetic index entries
35 entriesTerms in the official ICD-10-CM index that lead to D51.0.
- Addison's › anemia (pernicious)
- Addison-Biermer anemia (pernicious)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › Addison (-Biermer) (pernicious)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › Biermer's (pernicious)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › combined system disease NEC
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › congenital › pernicious
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › cytogenic
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › vitamin B12 NOS › due to › intrinsic factor deficiency
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › deficiency › vitamin B12 NOS › pernicious
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › malignant (progressive)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › pernicious (congenital) (malignant) (progressive)
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › progressive › malignant
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › progressive › pernicious
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) › vitamin › B12 deficiency (dietary) pernicious
- Biermer's (pernicious) anemia or disease
- Congenital › intrinsic factor deficiency
- Deficiency, deficient › intrinsic › factor (congenital)
- Degeneration, degenerative › combined (spinal cord) (subacute) › with anemia (pernicious)
- Disease, diseased › Addison's anemia (pernicious)
- Disease, diseased › Biermer's (pernicious anemia)
- Disease, diseased › Lichtheim's (subacute combined sclerosis with pernicious anemia)
- Disease, diseased › Putnam's (subacute combined sclerosis with pernicious anemia)
- Disease, diseased › Runeberg's (progressive pernicious anemia)
- Glossitis (chronic superficial) (gangrenous) (Moeller's) › Hunter's
- Hunter's › glossitis
- Lichtheim's disease or syndrome
- Myasthenia › syndrome › in › pernicious anemia
- Myelopathy (spinal cord) › in (due to) › pernicious anemia
- Neuropathy, neuropathic › vitamin B12 › with anemia (pernicious)
- Polyneuropathy (peripheral) › in (due to) › vitamin B12 deficiency › with anemia (pernicious)
- Runeberg's disease
- Syndrome › Dana-Putnam
- Syndrome › hunterian glossitis
- Syndrome › Lichtheim's
- Syndrome › Putnam-Dana
Codes whose notes reference D51.0
- G32.0Code first
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 16 · Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders
ICD-9-CM equivalent
Converter →- 281.0Pernicious anemiaapproximate
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about D51.0
Is D51.0 billable?
- Yes. D51.0 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D51.0 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D51.0 as a principal diagnosis.
Is D51.0 a CC or MCC?
- No. D51.0 is neither a CC nor an MCC under MS-DRG v44.0.
What DRG does D51.0 group to?
- D51.0 is used in the MS-DRG v44.0 logic for MS-DRG 811 (Red Blood Cell Disorders with MCC) and MS-DRG 812 (Red Blood Cell Disorders without MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for D51.0?
- The CMS General Equivalence Mappings map D51.0 to ICD-9-CM 281.0.