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ICD-10-CM 2027 diagnosis code

E16Other disorders of pancreatic internal secretion

Not billable — use a more specific code

E16 is a header code, so it can't be reported by itself. Choose one of the 8 more specific codes beneath it.

Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS, effective October 1, 2026. Updated September 29, 2026. About our data

About E16

E16 is the ICD-10-CM diagnosis code for other disorders of pancreatic internal secretion. It belongs to block E15-E16 (other disorders of glucose regulation and pancreatic internal secretion) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 8 subcodes must be used instead.

To report this condition, pick the subcode that matches the documentation: E16.0 (coma), E16.1 (hypoglycemia), E16.2 (unspecified), E16.3 (glucagon), E16.4 (gastrin), E16.8 (secretion), E16.9 (unspecified) and E16.A (level).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under E16

Notes that apply from higher levels

Instructions written at a parent level also apply to E16.

Broader instructions also apply from Chapter 4: Endocrine, nutritional and metabolic diseases.

Codes whose notes reference E16

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E16

Is E16 billable?

No. E16 is a header code. Report one of its more specific subcodes instead.