E16.2Hypoglycemia, unspecified

E16.2 is the ICD-10-CM diagnosis code for hypoglycemia, unspecified. It belongs to category E16 (other disorders of pancreatic internal secretion), block E15-E16 (other disorders of glucose regulation and pancreatic internal secretion) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E16, choose E16.2 (Hypoglycemia, unspecified) only when documentation doesn't support a more specific option: drug-induced hypoglycemia without coma (E16.0), other hypoglycemia (E16.1), increased secretion of glucagon (E16.3), increased secretion of gastrin (E16.4), other specified disorders of pancreatic internal secretion (E16.8), disorder of pancreatic internal secretion, unspecified (E16.9) and hypoglycemia level (E16.A).

Don't report E16.2 together with the conditions in its Excludes1 note: diabetes with hypoglycemia (E08.649, E10.649, E11.649, E13.649).

Use an additional code for hypoglycemia level, if applicable (E16.A-).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 640 (Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes with MCC, relative weight 1.3395) and DRG 641 (Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes without MCC, relative weight 0.7865), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 251.2 (hypoglycemia, unspecified).