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ICD-10-CM 2027 diagnosis code

E89.3Postprocedural hypopituitarism

✓ Billable / specific

E89.3 is a valid, billable ICD-10-CM code for postprocedural hypopituitarism. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E89.3

E89.3 is the ICD-10-CM diagnosis code for postprocedural hypopituitarism. It belongs to category E89 (postprocedural endocrine and metabolic complications and disorders, not elsewhere classified), block E89 (postprocedural endocrine and metabolic complications and disorders, not elsewhere classified) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within E89 (postprocedural endocrine and metabolic complications and disorders, not elsewhere classified), E89.3 is specifically for postprocedural hypopituitarism. Related codes cover postprocedural hypothyroidism (E89.0), postprocedural hypoinsulinemia (E89.1), postprocedural hypoparathyroidism (E89.2), postprocedural ovarian failure (E89.4), postprocedural testicular hypofunction (E89.5), postprocedural adrenocortical (-medullary) hypofunction (E89.6) and other postprocedural endocrine and metabolic complications and disorders (E89.8).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 253.7 (iatrogenic pituitary disorders).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Postirradiation hypopituitarism

Notes that apply from higher levels

Instructions written at a parent level also apply to E89.3.

› From E89 Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified
Excludes2
  • intraoperative complications of endocrine system organ or structure (E36.0-, E36.1-, E36.8)

Broader instructions also apply from Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

8 entries

Terms in the official ICD-10-CM index that lead to E89.3.

Codes whose notes reference E89.3

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 253.7Iatrogenic pituitary disordersapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E89.3

Is E89.3 billable?

Yes. E89.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E89.3 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict E89.3 as a principal diagnosis.

Is E89.3 a CC or MCC?

No. E89.3 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does E89.3 group to?

E89.3 is used in the MS-DRG v44.0 logic for MS-DRG 643 (Endocrine Disorders with MCC), MS-DRG 644 (Endocrine Disorders with CC) and MS-DRG 645 (Endocrine Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for E89.3?

The CMS General Equivalence Mappings map E89.3 to ICD-9-CM 253.7.