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ICD-10-CM 2027 diagnosis code

F33.3Major depressive disorder, recurrent, severe with psychotic symptoms

✓ Billable / specificCC — complication/comorbidity

F33.3 is a valid, billable ICD-10-CM code for major depressive disorder, recurrent, severe with psychotic symptoms. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Major depressv disorder, recurrent, severe w psych symptoms

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About F33.3

F33.3 is the ICD-10-CM diagnosis code for major depressive disorder, recurrent, severe with psychotic symptoms. It belongs to category F33 (major depressive disorder, recurrent), block F30-F39 (mood [affective] disorders) and chapter 5 (mental, Behavioral and Neurodevelopmental disorders). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within F33 (major depressive disorder, recurrent), F33.3 is specifically for major depressive disorder, recurrent, severe with psychotic symptoms. Related codes cover mild (F33.0), moderate (F33.1), severe without psychotic features (F33.2), in remission (F33.4), other recurrent depressive disorders (F33.8) and unspecified (F33.9).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 885 (Psychoses, relative weight 1.3901), in MDC 19 (Mental Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 296.34 (major depressive affective disorder, recurrent episode, severe, specified as with psychotic behavior) and 298.0 (depressive type psychosis).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Endogenous depression with psychotic symptoms
  • Major depressive disorder, recurrent, with psychotic features
  • Recurrent severe episodes of major depression with mood-congruent psychotic symptoms
  • Recurrent severe episodes of major depression with mood-incongruent psychotic symptoms
  • Recurrent severe episodes of major depression with psychotic symptoms
  • Recurrent severe episodes of psychogenic depressive psychosis
  • Recurrent severe episodes of psychotic depression
  • Recurrent severe episodes of reactive depressive psychosis

Notes that apply from higher levels

Instructions written at a parent level also apply to F33.3.

› From F33 Major depressive disorder, recurrent
Includes
  • recurrent episodes of depressive reaction
  • recurrent episodes of endogenous depression
  • recurrent episodes of major depression
  • recurrent episodes of psychogenic depression
  • recurrent episodes of reactive depression
  • recurrent episodes of seasonal affective disorder
  • recurrent episodes of seasonal depressive disorder
  • recurrent episodes of vital depression
Excludes1
  • bipolar disorder (F31.-)
  • manic episode (F30.-)

Broader instructions also apply from Chapter 5: Mental, Behavioral and Neurodevelopmental disorders.

Alphabetic index entries

6 entries

Terms in the official ICD-10-CM index that lead to F33.3.

Codes whose notes reference F33.3

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 19 · Mental Diseases and Disorders

ICD-9-CM equivalent

Converter →
  • 296.34Major depressive affective disorder, recurrent episode, severe, specified as with psychotic behaviorapproximate
  • 298.0Depressive type psychosisapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about F33.3

Is F33.3 billable?

Yes. F33.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can F33.3 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict F33.3 as a principal diagnosis.

Is F33.3 a CC or MCC?

F33.3 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does F33.3 group to?

F33.3 is used in the MS-DRG v44.0 logic for MS-DRG 885 (Psychoses). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for F33.3?

The CMS General Equivalence Mappings map F33.3 to ICD-9-CM 296.34 and 298.0.