P22.0Respiratory distress syndrome of newborn

P22.0 is the ICD-10-CM diagnosis code for respiratory distress syndrome of newborn. It belongs to category P22 (respiratory distress of newborn), block P19-P29 (respiratory and cardiovascular disorders specific to the perinatal period) and chapter 16 (certain conditions originating in the perinatal period). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within P22 (respiratory distress of newborn), P22.0 is specifically for respiratory distress syndrome of newborn. Related codes cover transient tachypnea of newborn (P22.1), other respiratory distress of newborn (P22.8) and unspecified (P22.9).

The conditions in its Excludes2 note aren't part of P22.0, but may be coded alongside it if the patient has both: respiratory arrest of newborn (P28.81) and respiratory failure of newborn NOS (P28.5).

As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 790 (Extreme Immaturity or Respiratory Distress Syndrome, Neonate, relative weight 6.0146), in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 769 (respiratory distress syndrome in newborn).