P91.3Neonatal cerebral irritability

P91.3 is the ICD-10-CM diagnosis code for neonatal cerebral irritability. It belongs to category P91 (other disturbances of cerebral status of newborn), block P90-P96 (other disorders originating in the perinatal period) and chapter 16 (certain conditions originating in the perinatal period). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within P91 (other disturbances of cerebral status of newborn), P91.3 is specifically for neonatal cerebral irritability. Related codes cover neonatal cerebral ischemia (P91.0), acquired periventricular cysts of newborn (P91.1), neonatal cerebral leukomalacia (P91.2), neonatal cerebral depression (P91.4), neonatal coma (P91.5), hypoxic ischemic encephalopathy [HIE] (P91.6), other specified disturbances of cerebral status of newborn (P91.8) and disturbance of cerebral status of newborn, unspecified (P91.9).

As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075) and DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 779.2 (cerebral depression, coma, and other abnormal cerebral signs in fetus or newborn).