ICD-10-CM 2027 diagnosis code
QA0.0141Syntaxin-binding protein 1-related disorder
QA0.0141 is a valid, billable ICD-10-CM code for syntaxin-binding protein 1-related disorder. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Code last changed in FY2026 (effective October 1, 2025). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About QA0.0141
QA0.0141 is the ICD-10-CM diagnosis code for Syntaxin-binding protein 1-related disorder. It belongs to category QA0 (neurodevelopmental disorders related to specific genetic pathogenic variants), block QA0-QA1 (genetic disorders, not elsewhere classified) and chapter 17 (congenital malformations, deformations, chromosomal abnormalities, and genetic disorders). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within QA0.014 (neurodevelopmental disorders, related to pathogenic variants in synapse related genes), QA0.0141 is specifically for Syntaxin-binding protein 1-related disorder. Related codes cover DLG4-related synaptopathy (QA0.0142) and neurodevelopmental disorder, related to pathogenic variant in other synapse related gene (QA0.0149).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 564 (Other Musculoskeletal System and Connective Tissue Diagnoses with MCC, relative weight 1.4908), DRG 565 (Other Musculoskeletal System and Connective Tissue Diagnoses with CC, relative weight 0.9783) and DRG 566 (Other Musculoskeletal System and Connective Tissue Diagnoses without CC/MCC, relative weight 0.7378), in MDC 08 (Diseases and Disorders of the Musculoskeletal System and Connective Tissue), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It is exempt from present-on-admission (POA) reporting, so no POA indicator is required.
It was added in FY2026, effective October 1, 2025.
Coding notes
- STXBP1-related disorders
Notes that apply from higher levels
Instructions written at a parent level also apply to QA0.0141.
Broader instructions also apply from Chapter 17: Congenital malformations, deformations, chromosomal abnormalities, and genetic disorders.
Alphabetic index entries
2 entriesTerms in the official ICD-10-CM index that lead to QA0.0141.
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 08 · Diseases and Disorders of the Musculoskeletal System and Connective Tissue
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2026 (effective 10/1/2025): Added
- No changes since FY2026.
Common questions about QA0.0141
Is QA0.0141 billable?
- Yes. QA0.0141 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can QA0.0141 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict QA0.0141 as a principal diagnosis.
Is QA0.0141 a CC or MCC?
- QA0.0141 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.
What DRG does QA0.0141 group to?
- QA0.0141 is used in the MS-DRG v44.0 logic for MS-DRG 564 (Other Musculoskeletal System and Connective Tissue Diagnoses with MCC), MS-DRG 565 (Other Musculoskeletal System and Connective Tissue Diagnoses with CC) and MS-DRG 566 (Other Musculoskeletal System and Connective Tissue Diagnoses without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.