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ICD-10-CM 2027 diagnosis code

R76.12Nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis

✓ Billable / specific

R76.12 is a valid, billable ICD-10-CM code for nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Nonspec reaction to gamma intrfrn respns w/o actv tubrclosis

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About R76.12

R76.12 is the ICD-10-CM diagnosis code for nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis. It belongs to category R76 (other abnormal immunological findings in serum), block R70-R79 (abnormal findings on examination of blood, without diagnosis) and chapter 18 (symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within R76.1, choose R76.12 (cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis) only when documentation doesn't support a more specific option: tuberculin skin test without active tuberculosis (R76.11).

Don't report R76.12 together with the conditions in its Excludes1 note: nonspecific reaction to tuberculin skin test without active tuberculosis (R76.11) and positive tuberculin skin test (R76.11).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 177 (Respiratory Infections and Inflammations with MCC, relative weight 1.6092), DRG 178 (Respiratory Infections and Inflammations with CC, relative weight 0.9744) and DRG 179 (Respiratory Infections and Inflammations without CC/MCC, relative weight 0.7345), in MDC 04 (Diseases and Disorders of the Respiratory System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 795.52 (nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosis).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Nonspecific reaction to QuantiFERON-TB test (QFT) without active tuberculosis
Excludes1Not coded here — never report together with this code
  • nonspecific reaction to tuberculin skin test without active tuberculosis (R76.11)
  • positive tuberculin skin test (R76.11)

Notes that apply from higher levels

Instructions written at a parent level also apply to R76.12.

Broader instructions also apply from R70-R79 Abnormal findings on examination of blood, without diagnosis and Chapter 18: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified.

Alphabetic index entries

2 entries

Terms in the official ICD-10-CM index that lead to R76.12.

Codes whose notes reference R76.12

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 795.52Nonspecific reaction to cell mediated immunity measurement of gamma interferon antigen response without active tuberculosisexact

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about R76.12

Is R76.12 billable?

Yes. R76.12 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can R76.12 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict R76.12 as a principal diagnosis.

Is R76.12 a CC or MCC?

No. R76.12 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does R76.12 group to?

R76.12 is used in the MS-DRG v44.0 logic for MS-DRG 177 (Respiratory Infections and Inflammations with MCC), MS-DRG 178 (Respiratory Infections and Inflammations with CC) and MS-DRG 179 (Respiratory Infections and Inflammations without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for R76.12?

The CMS General Equivalence Mappings map R76.12 to ICD-9-CM 795.52.