R85.81Anal high risk human papillomavirus (HPV) DNA test positive

R85.81 is the ICD-10-CM diagnosis code for anal high risk human papillomavirus (HPV) DNA test positive. It belongs to category R85 (abnormal findings in specimens from digestive organs and abdominal cavity), block R83-R89 (abnormal findings on examination of other body fluids, substances and tissues, without diagnosis) and chapter 18 (symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within R85.8 (other abnormal findings in specimens from digestive organs and abdominal cavity), R85.81 is specifically for anal high risk human papillomavirus (HPV) DNA test positive. Related codes cover anal low risk human papillomavirus (HPV) DNA test positive (R85.82) and other abnormal findings in specimens from digestive organs and abdominal cavity (R85.89).

Don't report R85.81 together with the conditions in its Excludes1 note: anogenital warts due to human papillomavirus (HPV) (A63.0) and condyloma acuminatum (A63.0).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 393 (Other Digestive System Diagnoses with MCC, relative weight 1.5881), DRG 394 (Other Digestive System Diagnoses with CC, relative weight 0.9228) and DRG 395 (Other Digestive System Diagnoses without CC/MCC, relative weight 0.6382), in MDC 06 (Diseases and Disorders of the Digestive System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 796.75 (anal high risk human papillomavirus (HPV) DNA test positive).