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ICD-10-CM 2027 diagnosis code

T45.AXPoisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs

Not billable — use a more specific codeRequires 7th character

T45.AX is a header code, so it can't be reported by itself. Choose one of the 6 more specific codes beneath it and add the required 7th character.Short description: Immune checkpoint inhibitors and immunostimulant drugs

Code last changed in FY2025 (effective October 1, 2024). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About T45.AX

T45.AX is the ICD-10-CM diagnosis code for poisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs. It belongs to category T45 (poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified), block T36-T50 (poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances) and chapter 19 (injury, poisoning and certain other consequences of external causes). It is a header code, so it can't be reported by itself; one of its 6 subcodes must be used instead.

Codes in this range require a 7th character: A for initial encounter, D for subsequent encounter and S for sequela. Use placeholder "X" characters to fill any empty positions before the 7th character.

It was added in FY2025, effective October 1, 2024.

7th character

The appropriate 7th character is to be added to each code from category T45

  • Ainitial encounter
  • Dsubsequent encounter
  • Ssequela

Notes that apply from higher levels

Instructions written at a parent level also apply to T45.AX.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2025 (effective 10/1/2024): Added
  • No changes since FY2025.

Common questions about T45.AX

Is T45.AX billable?

No. T45.AX is a header code. Report one of its more specific subcodes instead.