ICD-10-CM 2027 diagnosis code
T45.AX4Poisoning by immune checkpoint inhibitors and immunostimulant drugs, undetermined
T45.AX4 is a header code, so it can't be reported by itself. Choose one of the 3 more specific codes beneath it and add the required 7th character.Short description: Poisoning by immune chkpt inhibtr/immunostim drugs, undet
Code last changed in FY2025 (effective October 1, 2024). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About T45.AX4
T45.AX4 is the ICD-10-CM diagnosis code for poisoning by immune checkpoint inhibitors and immunostimulant drugs, undetermined. It belongs to category T45 (poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified), block T36-T50 (poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances) and chapter 19 (injury, poisoning and certain other consequences of external causes). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.
Within T45.AX (poisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs), T45.AX4 is specifically for poisoning by immune checkpoint inhibitors and immunostimulant drugs, undetermined. Related codes cover poisoning by immune checkpoint inhibitors and immunostimulant drugs, accidental (unintentional) (T45.AX1), poisoning by immune checkpoint inhibitors and immunostimulant drugs, intentional self-harm (T45.AX2), poisoning by immune checkpoint inhibitors and immunostimulant drugs, assault (T45.AX3), adverse effect of immune checkpoint inhibitors and immunostimulant drugs (T45.AX5) and underdosing of immune checkpoint inhibitors and immunostimulant drugs (T45.AX6).
Codes in this range require a 7th character: A for initial encounter, D for subsequent encounter and S for sequela. Use placeholder "X" characters to fill any empty positions before the 7th character.
It was added in FY2025, effective October 1, 2024.
7th character
The appropriate 7th character is to be added to each code from category T45
Notes that apply from higher levels
Instructions written at a parent level also apply to T45.AX4.
› From T45.A Poisoning by, adverse effect of and underdosing of immune checkpoint inhibitors and immunostimulant drugs
- poisoning by, adverse effect of and underdosing of antineoplastic and immunosuppressive drug (T45.1)
Broader instructions also apply from T36-T50 Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances and Chapter 19: Injury, poisoning and certain other consequences of external causes.
Table of Drugs & Neoplasms entries
- Immune › checkpoint inhibitors — Poisoning Undetermined
- Immunostimulant drug — Poisoning Undetermined
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2025 (effective 10/1/2024): Added
- No changes since FY2025.
Common questions about T45.AX4
Is T45.AX4 billable?
- No. T45.AX4 is a header code. Report one of its more specific subcodes instead.