ICD-10-CM 2027 diagnosis code
T46.905Adverse effect of unspecified agents primarily affecting the cardiovascular system
T46.905 is a header code, so it can't be reported by itself. Choose one of the 3 more specific codes beneath it and add the required 7th character.Short description: Adverse effect of unsp agents aff the cardiovascular sys
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About T46.905
T46.905 is the ICD-10-CM diagnosis code for adverse effect of unspecified agents primarily affecting the cardiovascular system. It belongs to category T46 (poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system), block T36-T50 (poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances) and chapter 19 (injury, poisoning and certain other consequences of external causes). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.
Within T46.90, choose T46.905 (Adverse effect of unspecified agents primarily affecting the cardiovascular system) only when documentation doesn't support a more specific option: poisoning by unspecified agents primarily affecting the cardiovascular system, accidental (unintentional) (T46.901), poisoning by unspecified agents primarily affecting the cardiovascular system, intentional self-harm (T46.902), poisoning by unspecified agents primarily affecting the cardiovascular system, assault (T46.903), poisoning by unspecified agents primarily affecting the cardiovascular system, undetermined (T46.904) and underdosing of unspecified agents primarily affecting the cardiovascular system (T46.906).
Codes in this range require a 7th character: A for initial encounter, D for subsequent encounter and S for sequela. Use placeholder "X" characters to fill any empty positions before the 7th character.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
7th character
The appropriate 7th character is to be added to each code from category T46
Notes that apply from higher levels
Instructions written at a parent level also apply to T46.905.
› From T46 Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system
- poisoning by, adverse effect of and underdosing of metaraminol (T44.4)
Broader instructions also apply from T36-T50 Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances and Chapter 19: Injury, poisoning and certain other consequences of external causes.
Table of Drugs & Neoplasms entries
- Capillary-active drug NEC — Adverse effect
- Cardiovascular drug NEC — Adverse effect
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about T46.905
Is T46.905 billable?
- No. T46.905 is a header code. Report one of its more specific subcodes instead.