Skip to content
Dx

ICD-10-CM 2027 diagnosis code

T46.905Adverse effect of unspecified agents primarily affecting the cardiovascular system

Not billable — use a more specific codeRequires 7th character

T46.905 is a header code, so it can't be reported by itself. Choose one of the 3 more specific codes beneath it and add the required 7th character.Short description: Adverse effect of unsp agents aff the cardiovascular sys

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About T46.905

T46.905 is the ICD-10-CM diagnosis code for adverse effect of unspecified agents primarily affecting the cardiovascular system. It belongs to category T46 (poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system), block T36-T50 (poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances) and chapter 19 (injury, poisoning and certain other consequences of external causes). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.

Within T46.90, choose T46.905 (Adverse effect of unspecified agents primarily affecting the cardiovascular system) only when documentation doesn't support a more specific option: poisoning by unspecified agents primarily affecting the cardiovascular system, accidental (unintentional) (T46.901), poisoning by unspecified agents primarily affecting the cardiovascular system, intentional self-harm (T46.902), poisoning by unspecified agents primarily affecting the cardiovascular system, assault (T46.903), poisoning by unspecified agents primarily affecting the cardiovascular system, undetermined (T46.904) and underdosing of unspecified agents primarily affecting the cardiovascular system (T46.906).

Codes in this range require a 7th character: A for initial encounter, D for subsequent encounter and S for sequela. Use placeholder "X" characters to fill any empty positions before the 7th character.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

7th character

The appropriate 7th character is to be added to each code from category T46

Notes that apply from higher levels

Instructions written at a parent level also apply to T46.905.

Table of Drugs & Neoplasms entries

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about T46.905

Is T46.905 billable?

No. T46.905 is a header code. Report one of its more specific subcodes instead.