ICD-10-CM 2027 diagnosis code
T46Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system
Not billable — use a more specific code
T46 is a header code, so it can't be reported by itself. Choose one of the 10 more specific codes beneath it.Short description: Agents primarily affecting the cardiovascular system
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About T46
T46 is the ICD-10-CM diagnosis code for poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system. It belongs to block T36-T50 (poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances) and chapter 19 (injury, poisoning and certain other consequences of external causes). It is a header code, so it can't be reported by itself; one of its 10 subcodes must be used instead.
To report this condition, pick the subcode that matches the documentation: T46.0 (action), T46.1 (blockers), T46.2 (classified), T46.3 (vasodilators), T46.4 (inhibitors), T46.5 (drugs), T46.6 (drugs), T46.7 (vasodilators) and 2 more.
Don't report T46 together with the conditions in its Excludes1 note: poisoning by, adverse effect of and underdosing of metaraminol (T44.4).
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Specific codes under T46
- T46.0Poisoning by, adverse effect of and underdosing of cardiac-stimulant glycosides and drugs of similar action
- T46.0XPoisoning by, adverse effect of and underdosing of cardiac-stimulant glycosides and drugs of similar action
- T46.0X1Poisoning by cardiac-stimulant glycosides and drugs of similar action, accidental (unintentional)
- T46.0X2Poisoning by cardiac-stimulant glycosides and drugs of similar action, intentional self-harm
- T46.0X3Poisoning by cardiac-stimulant glycosides and drugs of similar action, assault
- T46.0X4Poisoning by cardiac-stimulant glycosides and drugs of similar action, undetermined
- T46.0X5Adverse effect of cardiac-stimulant glycosides and drugs of similar action
- T46.0X6Underdosing of cardiac-stimulant glycosides and drugs of similar action
- T46.0XPoisoning by, adverse effect of and underdosing of cardiac-stimulant glycosides and drugs of similar action
- T46.1Poisoning by, adverse effect of and underdosing of calcium-channel blockers
- T46.1XPoisoning by, adverse effect of and underdosing of calcium-channel blockers
- T46.1X1Poisoning by calcium-channel blockers, accidental (unintentional)
- T46.1X2Poisoning by calcium-channel blockers, intentional self-harm
- T46.1X3Poisoning by calcium-channel blockers, assault
- T46.1X4Poisoning by calcium-channel blockers, undetermined
- T46.1X5Adverse effect of calcium-channel blockers
- T46.1X6Underdosing of calcium-channel blockers
- T46.1XPoisoning by, adverse effect of and underdosing of calcium-channel blockers
- T46.2Poisoning by, adverse effect of and underdosing of other antidysrhythmic drugs, not elsewhere classified
- T46.2XPoisoning by, adverse effect of and underdosing of other antidysrhythmic drugs
- T46.2X1Poisoning by other antidysrhythmic drugs, accidental (unintentional)
- T46.2X2Poisoning by other antidysrhythmic drugs, intentional self-harm
- T46.2X3Poisoning by other antidysrhythmic drugs, assault
- T46.2X4Poisoning by other antidysrhythmic drugs, undetermined
- T46.2X5Adverse effect of other antidysrhythmic drugs
- T46.2X6Underdosing of other antidysrhythmic drugs
- T46.2XPoisoning by, adverse effect of and underdosing of other antidysrhythmic drugs
- T46.3Poisoning by, adverse effect of and underdosing of coronary vasodilators
- T46.3XPoisoning by, adverse effect of and underdosing of coronary vasodilators
- T46.3X1Poisoning by coronary vasodilators, accidental (unintentional)
- T46.3X2Poisoning by coronary vasodilators, intentional self-harm
- T46.3X3Poisoning by coronary vasodilators, assault
- T46.3X4Poisoning by coronary vasodilators, undetermined
- T46.3X5Adverse effect of coronary vasodilators
- T46.3X6Underdosing of coronary vasodilators
- T46.3XPoisoning by, adverse effect of and underdosing of coronary vasodilators
- T46.4Poisoning by, adverse effect of and underdosing of angiotensin-converting-enzyme inhibitors
- T46.4XPoisoning by, adverse effect of and underdosing of angiotensin-converting-enzyme inhibitors
- T46.4X1Poisoning by angiotensin-converting-enzyme inhibitors, accidental (unintentional)
- T46.4X2Poisoning by angiotensin-converting-enzyme inhibitors, intentional self-harm
- T46.4X3Poisoning by angiotensin-converting-enzyme inhibitors, assault
- T46.4X4Poisoning by angiotensin-converting-enzyme inhibitors, undetermined
- T46.4X5Adverse effect of angiotensin-converting-enzyme inhibitors
- T46.4X6Underdosing of angiotensin-converting-enzyme inhibitors
- T46.4XPoisoning by, adverse effect of and underdosing of angiotensin-converting-enzyme inhibitors
- T46.5Poisoning by, adverse effect of and underdosing of other antihypertensive drugs
- T46.5XPoisoning by, adverse effect of and underdosing of other antihypertensive drugs
- T46.5X1Poisoning by other antihypertensive drugs, accidental (unintentional)
- T46.5X2Poisoning by other antihypertensive drugs, intentional self-harm
- T46.5X3Poisoning by other antihypertensive drugs, assault
- T46.5X4Poisoning by other antihypertensive drugs, undetermined
- T46.5X5Adverse effect of other antihypertensive drugs
- T46.5X6Underdosing of other antihypertensive drugs
- T46.5XPoisoning by, adverse effect of and underdosing of other antihypertensive drugs
- T46.6Poisoning by, adverse effect of and underdosing of antihyperlipidemic and antiarteriosclerotic drugs
- T46.6XPoisoning by, adverse effect of and underdosing of antihyperlipidemic and antiarteriosclerotic drugs
- T46.6X1Poisoning by antihyperlipidemic and antiarteriosclerotic drugs, accidental (unintentional)
- T46.6X2Poisoning by antihyperlipidemic and antiarteriosclerotic drugs, intentional self-harm
- T46.6X3Poisoning by antihyperlipidemic and antiarteriosclerotic drugs, assault
- T46.6X4Poisoning by antihyperlipidemic and antiarteriosclerotic drugs, undetermined
- T46.6X5Adverse effect of antihyperlipidemic and antiarteriosclerotic drugs
- T46.6X6Underdosing of antihyperlipidemic and antiarteriosclerotic drugs
- T46.6XPoisoning by, adverse effect of and underdosing of antihyperlipidemic and antiarteriosclerotic drugs
- T46.7Poisoning by, adverse effect of and underdosing of peripheral vasodilators
- T46.7XPoisoning by, adverse effect of and underdosing of peripheral vasodilators
- T46.7X1Poisoning by peripheral vasodilators, accidental (unintentional)
- T46.7X2Poisoning by peripheral vasodilators, intentional self-harm
- T46.7X3Poisoning by peripheral vasodilators, assault
- T46.7X4Poisoning by peripheral vasodilators, undetermined
- T46.7X5Adverse effect of peripheral vasodilators
- T46.7X6Underdosing of peripheral vasodilators
- T46.7XPoisoning by, adverse effect of and underdosing of peripheral vasodilators
- T46.8Poisoning by, adverse effect of and underdosing of antivaricose drugs, including sclerosing agents
- T46.8XPoisoning by, adverse effect of and underdosing of antivaricose drugs, including sclerosing agents
- T46.8X1Poisoning by antivaricose drugs, including sclerosing agents, accidental (unintentional)
- T46.8X2Poisoning by antivaricose drugs, including sclerosing agents, intentional self-harm
- T46.8X3Poisoning by antivaricose drugs, including sclerosing agents, assault
- T46.8X4Poisoning by antivaricose drugs, including sclerosing agents, undetermined
- T46.8X5Adverse effect of antivaricose drugs, including sclerosing agents
- T46.8X6Underdosing of antivaricose drugs, including sclerosing agents
- T46.8XPoisoning by, adverse effect of and underdosing of antivaricose drugs, including sclerosing agents
- T46.9Poisoning by, adverse effect of and underdosing of other and unspecified agents primarily affecting the cardiovascular system
- T46.90Poisoning by, adverse effect of and underdosing of unspecified agents primarily affecting the cardiovascular system
- T46.901Poisoning by unspecified agents primarily affecting the cardiovascular system, accidental (unintentional)
- T46.902Poisoning by unspecified agents primarily affecting the cardiovascular system, intentional self-harm
- T46.903Poisoning by unspecified agents primarily affecting the cardiovascular system, assault
- T46.904Poisoning by unspecified agents primarily affecting the cardiovascular system, undetermined
- T46.905Adverse effect of unspecified agents primarily affecting the cardiovascular system
- T46.906Underdosing of unspecified agents primarily affecting the cardiovascular system
- T46.99Poisoning by, adverse effect of and underdosing of other agents primarily affecting the cardiovascular system
- T46.991Poisoning by other agents primarily affecting the cardiovascular system, accidental (unintentional)
- T46.992Poisoning by other agents primarily affecting the cardiovascular system, intentional self-harm
- T46.993Poisoning by other agents primarily affecting the cardiovascular system, assault
- T46.994Poisoning by other agents primarily affecting the cardiovascular system, undetermined
- T46.995Adverse effect of other agents primarily affecting the cardiovascular system
- T46.996Underdosing of other agents primarily affecting the cardiovascular system
- T46.90Poisoning by, adverse effect of and underdosing of unspecified agents primarily affecting the cardiovascular system
Coding notes
Excludes1Not coded here — never report together with this code
- poisoning by, adverse effect of and underdosing of metaraminol (T44.4)
Notes that apply from higher levels
Instructions written at a parent level also apply to T46.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about T46
Is T46 billable?
- No. T46 is a header code. Report one of its more specific subcodes instead.