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ICD-10-CM 2027 diagnosis code

T80.41Rh incompatibility with hemolytic transfusion reaction

Not billable — use a more specific codeRequires 7th character

T80.41 is a header code, so it can't be reported by itself. Choose one of the 3 more specific codes beneath it and add the required 7th character.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About T80.41

T80.41 is the ICD-10-CM diagnosis code for Rh incompatibility with hemolytic transfusion reaction. It belongs to category T80 (complications following infusion, transfusion and therapeutic injection), block T80-T88 (complications of surgical and medical care, not elsewhere classified) and chapter 19 (injury, poisoning and certain other consequences of external causes). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.

Within T80.4 (Rh incompatibility reaction due to transfusion of blood or blood products), T80.41 is specifically for Rh incompatibility with hemolytic transfusion reaction. Related codes cover unspecified (T80.40) and other Rh incompatibility reaction due to transfusion of blood or blood products (T80.49).

Codes in this range require a 7th character: A for initial encounter, D for subsequent encounter and S for sequela. Use placeholder "X" characters to fill any empty positions before the 7th character.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

7th character

The appropriate 7th character is to be added to each code from category T80

  • Ainitial encounter
  • Dsubsequent encounter
  • Ssequela

Notes that apply from higher levels

Instructions written at a parent level also apply to T80.41.

› From T80 Complications following infusion, transfusion and therapeutic injection
Includes
  • complications following perfusion
Excludes2
  • bone marrow transplant rejection (T86.01)
  • febrile nonhemolytic transfusion reaction (R50.84)
  • fluid overload due to transfusion (E87.71)
  • posttransfusion purpura (D69.51)
  • transfusion associated circulatory overload (TACO) (E87.71)
  • transfusion (red blood cell) associated hemochromatosis (E83.111)
  • transfusion related acute lung injury (TRALI) (J95.84)

Broader instructions also apply from T80-T88 Complications of surgical and medical care, not elsewhere classified and Chapter 19: Injury, poisoning and certain other consequences of external causes.

Codes whose notes reference T80.41

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about T80.41

Is T80.41 billable?

No. T80.41 is a header code. Report one of its more specific subcodes instead.