ICD-10-CM 2027 diagnosis code
Y64.1Contaminated medical or biological substance, injected or used for immunization
Y64.1 is a valid, billable ICD-10-CM code for contaminated medical or biological substance, injected or used for immunization. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Contaminated med/biolog sub, injected or used for immuniz
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About Y64.1
Y64.1 is the ICD-10-CM diagnosis code for contaminated medical or biological substance, injected or used for immunization. It belongs to category Y64 (contaminated medical or biological substances), block Y62-Y69 (misadventures to patients during surgical and medical care) and chapter 20 (external causes of morbidity). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within Y64 (contaminated medical or biological substances), Y64.1 is specifically for contaminated medical or biological substance, injected or used for immunization. Related codes cover substance, transfused or infused (Y64.0), substance administered by other means (Y64.8) and substance administered by unspecified means (Y64.9).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as E875.1 (contaminated substance injected or used for vaccination).
Notes that apply from higher levels
Instructions written at a parent level also apply to Y64.1.
Broader instructions also apply from Y62-Y69 Misadventures to patients during surgical and medical care and Chapter 20: External causes of morbidity.
Alphabetic index entries
3 entriesTerms in the official ICD-10-CM index that lead to Y64.1.
- Misadventure (s) to patient(s) during surgical or medical care › contaminated medical or biological substance (blood, drug, fluid) › administered (by) NEC › immunization
- Misadventure (s) to patient(s) during surgical or medical care › contaminated medical or biological substance (blood, drug, fluid) › administered (by) NEC › injection
- Misadventure (s) to patient(s) during surgical or medical care › contaminated medical or biological substance (blood, drug, fluid) › administered (by) NEC › vaccination
ICD-9-CM equivalent
Converter →- E875.1Contaminated substance injected or used for vaccinationexact
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about Y64.1
Is Y64.1 billable?
- Yes. Y64.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can Y64.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict Y64.1 as a principal diagnosis.
Is Y64.1 a CC or MCC?
- No. Y64.1 is neither a CC nor an MCC under MS-DRG v44.0.