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ICD-10-CM 2027 diagnosis code

Z88Allergy status to drugs, medicaments and biological substances

Not billable — use a more specific code

Z88 is a header code, so it can't be reported by itself. Choose one of the 10 more specific codes beneath it.Short description: Allergy status to drug/meds/biol subst

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About Z88

Z88 is the ICD-10-CM diagnosis code for allergy status to drugs, medicaments and biological substances. It belongs to block Z77-Z99 (persons with potential health hazards related to family and personal history and certain conditions influencing health status) and chapter 21 (factors influencing health status and contact with health services). It is a header code, so it can't be reported by itself; one of its 10 subcodes must be used instead.

To report this condition, pick the subcode that matches the documentation: Z88.0 (penicillin), Z88.1 (agents), Z88.2 (sulfonamides), Z88.3 (agents), Z88.4 (agent), Z88.5 (agent), Z88.6 (agent), Z88.7 (vaccine) and 2 more.

The conditions in its Excludes2 note aren't part of Z88, but may be coded alongside it if the patient has both: Allergy status, other than to drugs and biological substances (Z91.0-).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under Z88

Coding notes

Excludes2Not included here — may be reported together if both conditions exist
  • Allergy status, other than to drugs and biological substances (Z91.0-)

Notes that apply from higher levels

Instructions written at a parent level also apply to Z88.

Codes whose notes reference Z88

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about Z88

Is Z88 billable?

No. Z88 is a header code. Report one of its more specific subcodes instead.