Z88.2Allergy status to sulfonamides

Z88.2 is the ICD-10-CM diagnosis code for allergy status to sulfonamides. It belongs to category Z88 (allergy status to drugs, medicaments and biological substances), block Z77-Z99 (persons with potential health hazards related to family and personal history and certain conditions influencing health status) and chapter 21 (factors influencing health status and contact with health services). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within Z88 (allergy status to drugs, medicaments and biological substances), Z88.2 is specifically for allergy status to sulfonamides. Related codes cover penicillin (Z88.0), other antibiotic agents (Z88.1), other anti-infective agents (Z88.3), anesthetic agent (Z88.4), narcotic agent (Z88.5), analgesic agent (Z88.6), serum and vaccine (Z88.7), other drugs, medicaments and biological substances (Z88.8) and 1 more.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 951 (Other Factors Influencing Health Status, relative weight 0.5577), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.

It is exempt from present-on-admission (POA) reporting, so no POA indicator is required.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2021 (title revised).

Before ICD-10, this condition was coded in ICD-9-CM as V14.2 (personal history of allergy to sulfonamides).