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ICD-10-CM 2027

ICD-10 code for acute myelofibrosis

C94.4

Acute panmyelosis with myelofibrosis

Header — needs a more specific code

From the official ICD-10-CM alphabetic index entry “Myelofibrosis › acute”. Page updated September 29, 2026.

About coding acute myelofibrosis

The ICD-10-CM code for acute myelofibrosis is C94.4 (Acute panmyelosis with myelofibrosis).

Within C94 (other leukemias of specified cell type), C94.4 is specifically for acute panmyelosis with myelofibrosis. Related codes cover acute erythroid leukemia (C94.0), acute megakaryoblastic leukemia (C94.2), mast cell leukemia (C94.3), myelodysplastic disease, not elsewhere classified (C94.6) and other specified leukemias (C94.8).

To report this condition, pick the subcode that matches the documentation: C94.40 (not having achieved remission), C94.41 (in remission) and C94.42 (in relapse).

Don't report C94.4 together with the conditions in its Excludes1 note: myelofibrosis NOS (D75.81) and secondary myelofibrosis NOS (D75.81).

Don't confuse with (Excludes1 for C94.4)

  • myelofibrosis NOS (D75.81)
  • secondary myelofibrosis NOS (D75.81)

Common questions about acute myelofibrosis ICD-10 codes

What is the ICD-10 code for acute myelofibrosis?

C94.4 — Acute panmyelosis with myelofibrosis (a header code; report a more specific subcode).

Is C94.4 billable?

No. C94.4 is a header code. Report one of its more specific subcodes instead.