ICD-10-CM 2027
ICD-10 code for alpha thalassemia
From the official ICD-10-CM alphabetic index entry “Thalassemia (anemia) (disease) › alpha (major) (severe) (triple gene defect)”. Page updated September 29, 2026.
About coding alpha thalassemia
The ICD-10-CM code for alpha thalassemia is D56.0 (Alpha thalassemia). The official index lists 3 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on D56.0.
Within D56 (thalassemia), D56.0 is specifically for alpha thalassemia. Related codes cover beta thalassemia (D56.1), Delta-beta thalassemia (D56.2), minor (D56.3), hereditary persistence of fetal hemoglobin [HPFH] (D56.4), hemoglobin E-beta thalassemia (D56.5), other thalassemias (D56.8) and unspecified (D56.9).
Don't report D56.0 together with the conditions in its Excludes1 note: alpha thalassemia trait or minor (D56.3), asymptomatic alpha thalassemia (D56.3), hydrops fetalis due to isoimmunization (P56.0) and hydrops fetalis not due to immune hemolysis (P83.2).
Use an additional code, if applicable, for hydrops fetalis due to alpha thalassemia (P56.99).
More specific alpha thalassemia codes (official index)
Don't confuse with (Excludes1 for D56.0)
Common questions about alpha thalassemia ICD-10 codes
What is the ICD-10 code for alpha thalassemia?
- D56.0 — Alpha thalassemia. More specific codes apply when the documentation supports them: D56.3, D56.3, D56.3.
What is the ICD-10 code for minor alpha thalassemia?
- D56.3 — Thalassemia minor.
What is the ICD-10 code for silent carrier alpha thalassemia?
- D56.3 — Thalassemia minor.
What is the ICD-10 code for trait alpha thalassemia?
- D56.3 — Thalassemia minor.
Is D56.0 billable?
- Yes. D56.0 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D56.0 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D56.0 as a principal diagnosis.
Is D56.0 a CC or MCC?
- No. D56.0 is neither a CC nor an MCC under MS-DRG v44.0.