Skip to content
Dx

ICD-10-CM 2027 diagnosis code

D56.3Thalassemia minor

✓ Billable / specific

D56.3 is a valid, billable ICD-10-CM code for thalassemia minor. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D56.3

D56.3 is the ICD-10-CM diagnosis code for thalassemia minor. It belongs to category D56 (thalassemia), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D56 (thalassemia), D56.3 is specifically for thalassemia minor. Related codes cover alpha thalassemia (D56.0), beta thalassemia (D56.1), Delta-beta thalassemia (D56.2), hereditary persistence of fetal hemoglobin [HPFH] (D56.4), hemoglobin E-beta thalassemia (D56.5), other thalassemias (D56.8) and unspecified (D56.9).

Don't report D56.3 together with the conditions in its Excludes1 note: alpha thalassemia (D56.0), beta thalassemia (D56.1), delta-beta thalassemia (D56.2), hemoglobin E-beta thalassemia (D56.5) and 1 more.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 811 (Red Blood Cell Disorders with MCC, relative weight 1.3988) and DRG 812 (Red Blood Cell Disorders without MCC, relative weight 0.9234), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 282.46 (thalassemia minor).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Alpha thalassemia minor
  • Alpha thalassemia silent carrier
  • Alpha thalassemia trait
  • Beta thalassemia minor
  • Beta thalassemia trait
  • Delta-beta thalassemia minor
  • Delta-beta thalassemia trait
  • Thalassemia trait NOS
Excludes1Not coded here — never report together with this code
  • alpha thalassemia (D56.0)
  • beta thalassemia (D56.1)
  • delta-beta thalassemia (D56.2)
  • hemoglobin E-beta thalassemia (D56.5)
  • sickle-cell trait (D57.3)

Notes that apply from higher levels

Instructions written at a parent level also apply to D56.3.

› From D56 Thalassemia
Excludes1
  • sickle-cell thalassemia (D57.4-)

Broader instructions also apply from Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.

Alphabetic index entries

11 entries

Terms in the official ICD-10-CM index that lead to D56.3.

Codes whose notes reference D56.3

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 16 · Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders

ICD-9-CM equivalent

Converter →

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about D56.3

Is D56.3 billable?

Yes. D56.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D56.3 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D56.3 as a principal diagnosis.

Is D56.3 a CC or MCC?

No. D56.3 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does D56.3 group to?

D56.3 is used in the MS-DRG v44.0 logic for MS-DRG 811 (Red Blood Cell Disorders with MCC) and MS-DRG 812 (Red Blood Cell Disorders without MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for D56.3?

The CMS General Equivalence Mappings map D56.3 to ICD-9-CM 282.46.