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ICD-10-CM 2027 diagnosis code

D56.1Beta thalassemia

✓ Billable / specific

D56.1 is a valid, billable ICD-10-CM code for beta thalassemia. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Looking up by condition? See ICD-10 code for Cooley's anemia, ICD-10 code for Beta severe thalassemia.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About D56.1

D56.1 is the ICD-10-CM diagnosis code for beta thalassemia. It belongs to category D56 (thalassemia), block D55-D59 (hemolytic anemias) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within D56 (thalassemia), D56.1 is specifically for beta thalassemia. Related codes cover alpha thalassemia (D56.0), Delta-beta thalassemia (D56.2), minor (D56.3), hereditary persistence of fetal hemoglobin [HPFH] (D56.4), hemoglobin E-beta thalassemia (D56.5), other thalassemias (D56.8) and unspecified (D56.9).

Don't report D56.1 together with the conditions in its Excludes1 note: beta thalassemia minor (D56.3), beta thalassemia trait (D56.3), delta-beta thalassemia (D56.2), hemoglobin E-beta thalassemia (D56.5) and 1 more.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075), DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), DRG 811 (Red Blood Cell Disorders with MCC, relative weight 1.3988) and DRG 812 (Red Blood Cell Disorders without MCC, relative weight 0.9234), in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period) and MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 282.44 (beta thalassemia).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Beta thalassemia major
  • Cooley's anemia
  • Homozygous beta thalassemia
  • Severe beta thalassemia
  • Thalassemia intermedia
  • Thalassemia major
Excludes1Not coded here — never report together with this code
  • beta thalassemia minor (D56.3)
  • beta thalassemia trait (D56.3)
  • delta-beta thalassemia (D56.2)
  • hemoglobin E-beta thalassemia (D56.5)
  • sickle-cell beta thalassemia (D57.4-)

Notes that apply from higher levels

Instructions written at a parent level also apply to D56.1.

› From D56 Thalassemia
Excludes1
  • sickle-cell thalassemia (D57.4-)

Broader instructions also apply from Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.

Alphabetic index entries

10 entries

Terms in the official ICD-10-CM index that lead to D56.1.

Codes whose notes reference D56.1

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period

MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period

MDC 16 · Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders

ICD-9-CM equivalent

Converter →

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about D56.1

Is D56.1 billable?

Yes. D56.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can D56.1 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict D56.1 as a principal diagnosis.

Is D56.1 a CC or MCC?

No. D56.1 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does D56.1 group to?

D56.1 is used in the MS-DRG v44.0 logic for MS-DRG 791 (Prematurity with Major Problems), MS-DRG 793 (Full Term Neonate with Major Problems), MS-DRG 811 (Red Blood Cell Disorders with MCC) and MS-DRG 812 (Red Blood Cell Disorders without MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for D56.1?

The CMS General Equivalence Mappings map D56.1 to ICD-9-CM 282.44.