ICD-10-CM 2027
ICD-10 code for Asthenia
From the official ICD-10-CM alphabetic index entry “Asthenia, asthenic”. Page updated September 29, 2026.
About coding Asthenia
The ICD-10-CM code for Asthenia is R53.1 (Weakness). The official index lists 17 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on R53.1.
Within R53 (malaise and fatigue), R53.1 is specifically for weakness. Related codes cover neoplastic (malignant) related fatigue (R53.0), functional quadriplegia (R53.2) and other malaise and fatigue (R53.8).
Don't report R53.1 together with the conditions in its Excludes1 note: age-related weakness (R54), muscle weakness (generalized) (M62.81), sarcopenia (M62.84) and senile asthenia (R54).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
More specific Asthenia codes (official index)
- cardiac I50.9 — Heart failure, unspecified
- psychogenic F45.8 — Other somatoform disorders
- cardiovascular I50.9 — Heart failure, unspecified
- psychogenic F45.8 — Other somatoform disorders
- heart I50.9 — Heart failure, unspecified
- psychogenic F45.8 — Other somatoform disorders
- hysterical F44.4 — Conversion disorder with motor symptom or deficit
- myocardial I50.9 — Heart failure, unspecified
- psychogenic F45.8 — Other somatoform disorders
- nervous F48.8 — Other specified nonpsychotic mental disorders
- neurocirculatory F45.8 — Other somatoform disorders
- neurotic F48.8 — Other specified nonpsychotic mental disorders
- psychogenic F48.8 — Other specified nonpsychotic mental disorders
- psychoneurotic F48.8 — Other specified nonpsychotic mental disorders
- psychophysiologic F48.8 — Other specified nonpsychotic mental disorders
- reaction (psychophysiologic) F48.8 — Other specified nonpsychotic mental disorders
- senile R54 — Age-related physical debility
Don't confuse with (Excludes1 for R53.1)
Common questions about Asthenia ICD-10 codes
What is the ICD-10 code for Asthenia?
- R53.1 — Weakness. More specific codes apply when the documentation supports them: I50.9, F45.8, I50.9, F45.8 and others below.
What is the ICD-10 code for cardiac asthenia?
- I50.9 — Heart failure, unspecified.
What is the ICD-10 code for cardiovascular asthenia?
- I50.9 — Heart failure, unspecified.
What is the ICD-10 code for heart asthenia?
- I50.9 — Heart failure, unspecified.
What is the ICD-10 code for hysterical asthenia?
- F44.4 — Conversion disorder with motor symptom or deficit.
What is the ICD-10 code for myocardial asthenia?
- I50.9 — Heart failure, unspecified.
What is the ICD-10 code for nervous asthenia?
- F48.8 — Other specified nonpsychotic mental disorders.
Is R53.1 billable?
- Yes. R53.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can R53.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict R53.1 as a principal diagnosis.
Is R53.1 a CC or MCC?
- No. R53.1 is neither a CC nor an MCC under MS-DRG v44.0.