ICD-10-CM 2027 diagnosis code

R53Malaise and fatigue

Not billable — use a more specific code

R53 is a header code, so it can't be reported by itself. Choose one of the 4 more specific codes beneath it.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About R53

R53 is the ICD-10-CM diagnosis code for malaise and fatigue. It belongs to block R50-R69 (general symptoms and signs) and chapter 18 (symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified). It is a header code, so it can't be reported by itself; one of its 4 subcodes must be used instead.

To report this condition, pick the subcode that matches the documentation: R53.0 (fatigue), R53.1 (weakness), R53.2 (quadriplegia) and R53.8 (fatigue).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under R53

Notes that apply from higher levels

Instructions written at a parent level also apply to R53.

Broader instructions also apply from Chapter 18: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified.

Code history

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2026
2027

FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
No changes since FY2016.

Common questions about R53

Is R53 billable?: No. R53 is a header code. Report one of its more specific subcodes instead.